PUBLICATION
Implication of microRNA deregulation in the response of vertebrates to endocrine disrupting chemicals
- Authors
- Cameron, B.E., Craig, P.M., Trudeau, V.L.
- ID
- ZDB-PUB-170214-183
- Date
- 2016
- Source
- Environmental toxicology and chemistry 35: 788-93 (Review)
- Registered Authors
- Trudeau, V.L.
- Keywords
- Ecotoxicology, Endocrine-disrupting chemicals, Fluoxetine, Pharmaceuticals, microRNA
- MeSH Terms
-
- Animals
- Antidepressive Agents/toxicity
- Aquatic Organisms/drug effects
- Aquatic Organisms/metabolism
- Endocrine Disruptors/toxicity*
- Endocrine System/drug effects
- Endocrine System/metabolism
- Fluoxetine/toxicity
- Goldfish/metabolism
- MicroRNAs/metabolism*
- Water Pollutants, Chemical/toxicity*
- Zebrafish/metabolism
- PubMed
- 25982118 Full text @ Environ. Toxicol. Chem.
Citation
Cameron, B.E., Craig, P.M., Trudeau, V.L. (2016) Implication of microRNA deregulation in the response of vertebrates to endocrine disrupting chemicals. Environmental toxicology and chemistry. 35:788-93.
Abstract
Micro ribonucleic acids (miRNAs) are recently discovered small regulatory molecules that control messenger RNA (mRNA) translation in plants and animals and have been implicated in a variety of hormone-related physiological pathways. Estrogens, thyroid hormones, and gonadotropins are all known to act on miRNA abundance to cause major shifts in cellular activity, physiology, and homeostatic control mechanisms. Research on cancer biology has also recently considered miRNA as therapeutic targets, because the deregulation of specific miRNAs in various tissues has been correlated with tumorigenesis and other carcinogenic responses. Because many pharmaceuticals are considered to be endocrine-disrupting chemicals (EDCs), their effects on miRNAs may be important to our understanding of basic physiological control and phenotypic outcomes of wildlife exposed to EDCs. Presented is a brief overview of the synthesis, control, and action of miRNAs, focusing on endocrine systems. The antidepressant fluoxetine will be used as an example for miRNA studies in aquatic species, one of the few examples in ecotoxicology. Given the mounting evidence that miRNAs are regulated by hormones, a clear need exists to investigate the potential for environmental EDCs to deregulate miRNA expression and action.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping