PUBLICATION
Renal progenitors: Roles in kidney disease and regeneration
- Authors
- Chambers, B.E., Wingert, R.A.
- ID
- ZDB-PUB-161209-3
- Date
- 2016
- Source
- World journal of stem cells 8: 367-375 (Review)
- Registered Authors
- Wingert, Rebecca
- Keywords
- Development, Kidney, Nephrogenesis, Nephron, Parietal epithelial cell, Regeneration, Renal progenitor, Tubular progenitor cell, Zebrafish
- MeSH Terms
- none
- PubMed
- 27928463 Full text @ World J Stem Cells
Citation
Chambers, B.E., Wingert, R.A. (2016) Renal progenitors: Roles in kidney disease and regeneration. World journal of stem cells. 8:367-375.
Abstract
Kidney disease is a devastating condition that affects millions of people worldwide, and its prevalence is predicted to significantly increase. The kidney is a complex organ encompassing many diverse cell types organized in a elaborate tissue architecture, making regeneration a challenging feat. In recent years, there has been a surge in the field of stem cell research to develop regenerative therapies for various organ systems. Here, we review some recent progressions in characterizing the role of renal progenitors in development, regeneration, and kidney disease in mammals. We also discuss how the zebrafish provides a unique experimental animal model that can provide a greater molecular and genetic understanding of renal progenitors, which may contribute to the development of potential regenerative therapies for human renal afflictions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping