PUBLICATION
Identification and expression of a new Ly6 gene cluster in zebrafish Danio rerio, with implications of being involved in embryonic immunity
- Authors
- Wang, M., Li, L., Guo, Q., Zhang, S., Ji, D., Li, H.
- ID
- ZDB-PUB-160414-3
- Date
- 2016
- Source
- Fish & shellfish immunology 54: 230-40 (Journal)
- Registered Authors
- Li, Hongyan
- Keywords
- LPS, Ly6 superfamily, digestive system, immunity, zebrafish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Antigens, Ly/genetics*
- Antigens, Ly/metabolism
- Embryo, Nonmammalian/immunology
- Gene Expression Regulation, Developmental*
- Immunity, Innate*
- Multigene Family*
- Protein Conformation
- Sequence Alignment/veterinary
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/immunology
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- PubMed
- 27071517 Full text @ Fish Shellfish Immunol.
Citation
Wang, M., Li, L., Guo, Q., Zhang, S., Ji, D., Li, H. (2016) Identification and expression of a new Ly6 gene cluster in zebrafish Danio rerio, with implications of being involved in embryonic immunity. Fish & shellfish immunology. 54:230-40.
Abstract
Lymphocyte antigen-6 (Ly6) superfamily is a large family of proteins and characterized by precisely spaced cysteine motifs, termed the three-finger fold. To date, a large number of members of the Ly6/uPAR family were identified among many species. In this study, we first report the identification and characterization of the secreted Ly2.1-3 proteins on the chromosome 2 in zebrafish and determine the expression pattern. Ly2.1-3 all possess a conserved LU domain and adopt similar three-finger structure with human CD59, SLURP1 and other Ly6 family members. Ly2.1-3 cluster on chromosome 2 and share high homology, possibly originated from chromosomal gene duplication. Ly2.1-3 exhibit distinct expression pattern in the endoderm, they were found abundantly and specifically in the digestive tract, liver and pancreas respectively. The differential expression pattern may suggest Ly2.1-3 acquire new function during gene duplication. The expression level of Ly2.1-3 were up-regulating challenged with LPS indicated that they have a role in innate immune responses of the digestive system during endotoxin challenge in early stage.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping