PUBLICATION
Interplay between cardiac function and heart development
- Authors
- Andrés-Delgado, L., Mercader, N.
- ID
- ZDB-PUB-160310-13
- Date
- 2016
- Source
- Biochimica et biophysica acta. Molecular cell research 1863(7 Pt B): 1707-16 (Review)
- Registered Authors
- Mercader Huber, Nadia
- Keywords
- Blood and pericardial flow, Cardiac development, Mechanosensing, Mechanotransduction, Mouse, Zebrafish
- MeSH Terms
-
- Action Potentials
- Adaptation, Physiological
- Age Factors
- Animals
- Coronary Circulation*
- Heart/embryology
- Heart/growth & development*
- Heart Diseases/pathology
- Heart Diseases/physiopathology
- Hemodynamics*
- Humans
- Mechanotransduction, Cellular*
- Morphogenesis
- Myocytes, Cardiac/metabolism
- Myocytes, Cardiac/physiology*
- Regeneration
- Stress, Mechanical
- PubMed
- 26952935 Full text @ BBA Molecular Cell Research
Citation
Andrés-Delgado, L., Mercader, N. (2016) Interplay between cardiac function and heart development. Biochimica et biophysica acta. Molecular cell research. 1863(7 Pt B):1707-16.
Abstract
Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease. This requires cardiomyocytes to be mechanically durable and able to mount coordinated responses to a variety of environmental signals on different time scales, including cardiac pressure loading and electrical and hemodynamic forces. During physiological growth, myocytes, endocardial and epicardial cells have to adaptively remodel to these mechanical forces. Here we review some of the recent advances in the understanding of how mechanical forces influence cardiac development, with a focus on fluid flow forces. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Develomental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping