PUBLICATION
Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae
- Authors
- MacDonald, T.C., Nehzati, S., Sylvain, N.J., James, A.K., Korbas, M., Caine, S., Pickering, I.J., George, G.N., Krone, P.H.
- ID
- ZDB-PUB-150801-7
- Date
- 2015
- Source
- Journal of inorganic biochemistry 151: 10-17 (Journal)
- Registered Authors
- Krone, Patrick H.
- Keywords
- Density functional theory, Mercury, Metal ion toxicology, Methylmercury, X-ray absorption spectroscopy, X-ray fluorescence imaging, Zebrafish
- MeSH Terms
-
- Animals
- Coordination Complexes/chemistry
- Enzyme Activation/drug effects
- Mercury Compounds/chemistry
- Mercury Compounds/toxicity*
- Phenylthiourea/chemistry
- Phenylthiourea/pharmacology*
- Quantum Theory
- Toxicological Phenomena/drug effects*
- Zebrafish
- PubMed
- 26226450 Full text @ J. Inorg. Biochem.
Citation
MacDonald, T.C., Nehzati, S., Sylvain, N.J., James, A.K., Korbas, M., Caine, S., Pickering, I.J., George, G.N., Krone, P.H. (2015) Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae. Journal of inorganic biochemistry. 151:10-17.
Abstract
In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. Here we show that PTU can have dramatic synergistic and antagonistic effects on the chemical toxicology of different mercury compounds. Our results indicate that extreme caution should be used when employing PTU in toxicological studies, particularly when studying toxic metal ions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping