PUBLICATION
Akap12 is essential for the morphogenesis of muscles involved in zebrafish locomotion
- Authors
- Kim, H., Kim, J., Jeong, J., Han, S., Kim, K.
- ID
- ZDB-PUB-141224-13
- Date
- 2014
- Source
- Differentiation; research in biological diversity 88(4-5): 106-16 (Journal)
- Registered Authors
- Keywords
- Development, Locomotion, Morphogenesis, Muscle, akap12
- MeSH Terms
-
- A Kinase Anchor Proteins/genetics
- A Kinase Anchor Proteins/metabolism*
- Animals
- Morphogenesis*
- Muscle, Skeletal/embryology
- Muscle, Skeletal/metabolism*
- Protein Isoforms/genetics
- Protein Isoforms/metabolism
- Swimming*
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 25534553 Full text @ Differentiation
Citation
Kim, H., Kim, J., Jeong, J., Han, S., Kim, K. (2014) Akap12 is essential for the morphogenesis of muscles involved in zebrafish locomotion. Differentiation; research in biological diversity. 88(4-5):106-16.
Abstract
Swimming behavior in fish is driven by coordinated contractions of muscle fibers. In zebrafish, slow muscle cell migration is crucial for the formation of the muscle network; slow myoblasts, which arise from medial adaxial cells, migrate radially to the lateral surface of the trunk and tail during embryogenesis. This study found that the zebrafish A-kinase anchoring protein (akap)12 isoforms akap12α and akap12β are required for muscle morphogenesis and locomotor activity. Embryos deficient in akap12 exhibited reduced spontaneous coiling, touch response, and free swimming. Akap12-depleted slow but not fast muscle cells were misaligned, suggesting that the behavioral abnormalities resulted from specific defects in slow muscle patterning; indeed, slow muscle cells and muscle pioneers in these embryos showed abnormal migration in a cell-autonomous manner. Taken together, these results suggest that akap12 plays a critical role in the development of zebrafish locomotion by regulating the normal morphogenesis of muscles.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping