PUBLICATION

Zebrafish Noxa promotes mitosis in early embryonic development and regulates apoptosis in subsequent embryogenesis

Authors
Zhong, J.X., Zhou, L., Li, Z., Wang, Y., Gui, J.F.
ID
ZDB-PUB-140513-391
Date
2014
Source
Cell death and differentiation   21: 1013-24 (Journal)
Registered Authors
Gui, Jian-Fang
Keywords
Noxa, Bik, Wnt4b, Mcl1, mitosis, apoptosis
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Apoptosis/genetics*
  • Embryo, Nonmammalian
  • Embryonic Development*
  • Gene Expression Regulation, Developmental
  • Mice
  • Mitosis/genetics*
  • Myeloid Cell Leukemia Sequence 1 Protein/metabolism
  • Proto-Oncogene Proteins c-bcl-2/biosynthesis*
  • Proto-Oncogene Proteins c-bcl-2/genetics
  • RNA, Messenger/biosynthesis
  • Wnt4 Protein/metabolism
  • Zebrafish
  • Zebrafish Proteins/metabolism
PubMed
24608793 Full text @ Cell Death Differ.
Abstract
Noxa functions in apoptosis and immune system of vertebrates, but its activities in embryo development remain unclear. In this study, we have studied the role of zebrafish Noxa (zNoxa) by using zNoxa-specifc morpholino knockdown and overexpression approaches in developing zebrafish embryos. Expression pattern analysis indicates that zNoxa transcript is of maternal origin, which displays a uniform distribution in early embryonic development until shield stage, and the zygote zNoxa transcription is initiated from this stage and mainly localized in YSL of the embryos. The zNoxa expression alterations result in strong embryonic development defects, demonstrating that zNoxa regulates apoptosis from 75% epiboly stage of development onward, in which zNoxa firstly induces the expression of zBik, and then cooperates with zBik to regulate apoptosis. Moreover, zNoxa knockdown also causes a reduction in number of mitotic cells before 8 h.p.f., suggesting that zNoxa also promotes mitosis before 75% epiboly stage. The effect of zNoxa on mitosis is mediated by zWnt4b in early embryos, whereas zMcl1a and zMcl1b suppress the ability of zNoxa to regulate mitosis and apoptosis at different developmental stages. In addition, mammalian mouse Noxa (mNoxa) mRNA was demonstrated to rescue the arrest of mitosis when zNoxa was knocked down, suggesting that mouse and zebrafish Noxa might have similar dual functions. Therefore, the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
Genes / Markers
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping