PUBLICATION
Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment
- Authors
- Vignet, C., Devier, M.H., Le Menach, K., Lyphout, L., Potier, J., Cachot, J., Budzinski, H., Bégout, M.L., Cousin, X.
- ID
- ZDB-PUB-140513-289
- Date
- 2014
- Source
- Environmental science and pollution research international 21(24): 13877-87 (Journal)
- Registered Authors
- Cousin, Xavier
- Keywords
- none
- MeSH Terms
-
- Animals
- Behavior, Animal/drug effects*
- Embryo, Nonmammalian/drug effects
- Female
- Geologic Sediments/chemistry*
- Male
- Polycyclic Aromatic Hydrocarbons/analysis
- Polycyclic Aromatic Hydrocarbons/toxicity*
- Reproduction/drug effects
- Water Pollutants, Chemical/analysis
- Water Pollutants, Chemical/toxicity*
- Zebrafish/growth & development*
- Zebrafish/physiology
- PubMed
- 24659400 Full text @ Environ. Sci. Pollut. Res. Int.
Citation
Vignet, C., Devier, M.H., Le Menach, K., Lyphout, L., Potier, J., Cachot, J., Budzinski, H., Bégout, M.L., Cousin, X. (2014) Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment. Environmental science and pollution research international. 21(24):13877-87.
Abstract
A natural sediment spiked with three individual polycyclic aromatic hydrocarbons (PAHs; pyrene, phenanthrene and benzo[a]pyrene) was used to expose zebrafish embryos and larvae during 4 days. The total PAH concentration was 4.4 μg g(-1) which is in the range found in sediment from contaminated areas. Quantification of metabolites in the larvae after exposure confirmed the actual contamination of the larvae and indicated an active metabolism especially for pyrene and benzo[a]pyrene. After a transfer in a clean medium, the larvae were reared to adulthood and evaluated for survival, growth, reproduction, and behavior. Measured endpoints revealed a late disruption of growth (appearing at 5 months) and a trend toward a lower reproductive ability. Adults of embryos exposed to sediment spiked with PAHs displayed lethargic and/or anxiety-like behaviors. This latter behavior was also identified in offspring at larval stage. All together, these effects could have detrimental consequences on fish performances and contribution to recruitment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping