PUBLICATION
Pten regulates zebrafish hematopoiesis
- Authors
- Langenau, D.M.
- ID
- ZDB-PUB-140226-2
- Date
- 2014
- Source
- Blood 123(2): 149-150 (Review)
- Registered Authors
- Langenau, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Differentiation/genetics*
- Hematopoietic Stem Cells/cytology*
- Hematopoietic Stem Cells/metabolism*
- PTEN Phosphohydrolase/genetics*
- PTEN Phosphohydrolase/metabolism*
- PubMed
- 24408201 Full text @ Blood
Citation
Langenau, D.M. (2014) Pten regulates zebrafish hematopoiesis. Blood. 123(2):149-150.
Abstract
In this issue of Blood, Choorapoikayil et al have used phosphatase and tensin homolog (Pten)–deficient zebrafish to uncover prominent roles for Pten loss in enhancing proliferation of hematopoietic stem cells (HSCs) and eliciting differentiation arrest within lineage-committed blood progenitor cells. These results provide novel insights into the early genetic events that predispose blood cells to malignant transformation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping