PUBLICATION
A generic organ based ontology system, applied to vertebrate heart anatomy, development and physiology
- Authors
- Bertens, L.M., Slob, J., and Verbeek, F.J.
- ID
- ZDB-PUB-130104-1
- Date
- 2011
- Source
- Journal of integrative bioinformatics 8(2): 167 (Journal)
- Registered Authors
- Verbeek, Fons J.
- Keywords
- none
- MeSH Terms
-
- Animals
- Computational Biology/methods*
- Heart/anatomy & histology*
- Heart/growth & development
- Heart/physiology*
- Organ Specificity
- Search Engine
- Species Specificity
- User-Computer Interface
- Vertebrates/anatomy & histology*
- PubMed
- 21900708 Full text @ J. Integr. Bioinform.
Citation
Bertens, L.M., Slob, J., and Verbeek, F.J. (2011) A generic organ based ontology system, applied to vertebrate heart anatomy, development and physiology. Journal of integrative bioinformatics. 8(2):167.
Abstract
We present a novel approach to modelling biological information using ontologies. The system interlinks three ontologies, comprising anatomical, developmental and taxonomical information, and includes instances of structures for different species. The framework is constructed for comparative analyses in the field of evolutionary development. We have applied the approach to the vertebrate heart and present four case studies of the functionality of the system, focusing on cross-species comparisons, developmental studies, physiological studies and 3D visualisation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping