PUBLICATION
Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish
- Authors
- Fujisawa, K., Terai, S., Hirose, Y., Takami, T., Yamamoto, N., and Sakaida, I.
- ID
- ZDB-PUB-111013-2
- Date
- 2011
- Source
- Biochemical and Biophysical Research Communications 414(2): 331-6 (Journal)
- Registered Authors
- Keywords
- zebrafish, liber tumors, aging, senescence marker protein 30 (SMP30), regucalcin
- MeSH Terms
-
- Aging/genetics
- Aging/metabolism*
- Animals
- Biomarkers/metabolism
- Carboxylic Ester Hydrolases/genetics
- Carboxylic Ester Hydrolases/metabolism*
- Cell Transformation, Neoplastic/genetics
- Cell Transformation, Neoplastic/metabolism*
- Liver/injuries
- Liver/metabolism*
- Liver Regeneration*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish/physiology*
- PubMed
- 21951853 Full text @ Biochem. Biophys. Res. Commun.
Citation
Fujisawa, K., Terai, S., Hirose, Y., Takami, T., Yamamoto, N., and Sakaida, I. (2011) Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish. Biochemical and Biophysical Research Communications. 414(2):331-6.
Abstract
Senescence marker protein 30 (SMP30)/regucalcin (RGN) is known to be related to aging, hepatocyte proliferation and tumorigenesis. However, expression and function of non-mammalian SMP30/RGN is poorly understood. We found that zebrafish SMP30/RGN mRNA expression decreases with aging, partial hepatectomy and thioacetamide-induced acute liver injury. SMP30/RGN expression was also greatly decreased in a zebrafish liver cell line. In addition, we induced liver tumors in adult zebrafish by administering diethylnitrosamine. Decreased expression was observed in foci, hepatocellular carcinomas, cholangiocellular carcinomas and mixed tumors as compared to the surrounding area. We thus showed the importance of SMP30/RGN in liver proliferation and tumorigenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping