PUBLICATION

Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish

Authors
Postel, R., Ketema, M., Kuikman, I., de Pereda, J.M., and Sonnenberg, A.
ID
ZDB-PUB-110214-20
Date
2011
Source
Journal of Cell Science   124(Pt 5): 755-764 (Journal)
Registered Authors
Postel, Ruben
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Cell Nucleus/metabolism*
  • Cell Nucleus/ultrastructure
  • Humans
  • Intermediate Filaments/metabolism*
  • Membrane Proteins/chemistry
  • Membrane Proteins/genetics
  • Membrane Proteins/metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Nuclear Proteins/chemistry
  • Nuclear Proteins/genetics
  • Nuclear Proteins/metabolism*
  • Protein Conformation
  • Protein Isoforms/chemistry
  • Protein Isoforms/genetics
  • Protein Isoforms/metabolism
  • Sequence Alignment
  • Zebrafish/anatomy & histology
  • Zebrafish/embryology
  • Zebrafish/metabolism*
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed
21303928 Full text @ J. Cell Sci.
Abstract
The outer nuclear membrane protein nesprin-3 binds the cytoskeletal linker protein plectin, which are proposed to anchor the intermediate filaments to the nuclear envelope. To investigate the function of nesprin-3 in vivo, we used the zebrafish as a vertebrate model system. Zebrafish nesprin-3 is expressed at the nuclear envelope of epidermal and skeletal muscle cells during development. Unexpectedly, loss of nesprin-3 did not affect embryonic development, viability or fertility. However, nesprin-3-deficient zebrafish embryos showed a reduced concentration of intermediate filaments around the nucleus. Additional analysis revealed the presence of two nesprin-3 isoforms in zebrafish, nesprin-3α and nesprin-3β. Nesprin-3β is only expressed during early development and lacks seven amino acids in its first spectrin repeat that are crucial for plectin binding and recruitment to the nuclear envelope. These seven amino acids are highly conserved and we showed that residues R43 and L44 within this motif are required for plectin binding. Furthermore, several residues in the actin-binding domain of plectin that are crucial for binding to the integrin β4 subunit are also important for the binding to nesprin-3α, indicating partial overlapping binding sequences for nesprin-3α and integrin β4. All this shows that nesprin-3 is dispensable for normal development in zebrafish, but important for mediating the association of the intermediate filament system with the nucleus in vivo.
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