PUBLICATION
Caldesmon is essential for cardiac morphogenesis and function: In vivo study using a zebrafish model
- Authors
- Zheng, P.P., Severijnen, L.A., Willemsen, R., and Kros, J.M.
- ID
- ZDB-PUB-081114-14
- Date
- 2009
- Source
- Biochemical and Biophysical Research Communications 378(1): 37-40 (Journal)
- Registered Authors
- Keywords
- Cardiac development, Myogenesis, Contractility, Caldesmon, Zebrafish model
- MeSH Terms
-
- Animals
- Calmodulin-Binding Proteins/genetics
- Calmodulin-Binding Proteins/physiology*
- Gene Knockdown Techniques
- Heart/embryology*
- Heart/physiology*
- Models, Animal
- Morphogenesis*/genetics
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 19000902 Full text @ Biochem. Biophys. Res. Commun.
Citation
Zheng, P.P., Severijnen, L.A., Willemsen, R., and Kros, J.M. (2009) Caldesmon is essential for cardiac morphogenesis and function: In vivo study using a zebrafish model. Biochemical and Biophysical Research Communications. 378(1):37-40.
Abstract
The zebrafish homologue of caldesmon is similar to the mammalian low molecular weight caldesmon (l-CaD). In this study, we explored the effects of caldesmon knockdown on vertebrate heart development in vivo. In a zebrafish model caldesmon was knocked down resulting in defective cardiac morphogenesis, muscularization and function. The data provide the first functional assessment of the role of caldesmon in cardiac development in vivo, and indicate that caldesmon is essential for proper cardiac organogenesis and function. Because caldesmon expression remarkably influences cardiac muscularization, the findings are relevant for designing future therapeutic strategies in the regeneration of cardiac damage.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping