PUBLICATION
Differentiation of the vertebrate retina is coordinated by an FGF signaling center
- Authors
- Martinez-Morales, J.R., Del Bene, F., Nica, G., Hammerschmidt, M., Bovolenta, P., and Wittbrodt, J.
- ID
- ZDB-PUB-080710-1
- Date
- 2005
- Source
- Developmental Cell 8(4): 565-574 (Journal)
- Registered Authors
- Bovolenta, Paola, Del Bene, Filippo, Hammerschmidt, Matthias, Martinez-Morales, Juan R., Nica, Gabriela
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Differentiation/physiology*
- Chick Embryo
- Fibroblast Growth Factors/genetics
- Fibroblast Growth Factors/metabolism*
- In Situ Hybridization
- Morphogenesis/physiology
- Retina/cytology*
- Retina/growth & development*
- Retina/metabolism
- Signal Transduction/physiology*
- Zebrafish/embryology
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 15809038 Full text @ Dev. Cell
Citation
Martinez-Morales, J.R., Del Bene, F., Nica, G., Hammerschmidt, M., Bovolenta, P., and Wittbrodt, J. (2005) Differentiation of the vertebrate retina is coordinated by an FGF signaling center. Developmental Cell. 8(4):565-574.
Abstract
In vertebrates, midline-derived sonic hedgehog and nodal are crucial for the initial proximal-distal patterning of the eye. The establishment of the distal optic stalk is in turn a prerequisite to initiate retinogenesis. However, the signal that activates this process is unknown. Here, we demonstrate that in both chick and fish, the initiation of retinal differentiation is triggered by a species-specific localized Fgf signaling center that acts as mediator of the midline signals. The concerted activity of Fgf8 and Fgf3 is both necessary and sufficient to coordinate retinal differentiation independent of the connecting optic stalk.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping