PUBLICATION
CYP1A/Regucalcin Gene Expression and Edema Formation in Zebrafish Embryos Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
- Authors
- Wu, Y.D., Jiang, L., Zhou, Z., Zheng, M.H., Zhang, J., and Liang, Y.
- ID
- ZDB-PUB-080515-8
- Date
- 2008
- Source
- Bulletin of environmental contamination and toxicology 80(6): 482-486 (Journal)
- Registered Authors
- Keywords
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Zebrafish, Edema, Gene expression
- MeSH Terms
-
- Animals
- Calcium-Binding Proteins/genetics*
- Calcium-Binding Proteins/metabolism
- Cytochrome P-450 CYP1A1/genetics*
- Cytochrome P-450 CYP1A1/metabolism
- Dose-Response Relationship, Drug
- Edema/chemically induced*
- Edema/embryology
- Edema/physiopathology
- Embryo, Nonmammalian/drug effects*
- Embryo, Nonmammalian/pathology
- Embryo, Nonmammalian/physiopathology
- Gene Expression Regulation, Developmental/drug effects*
- Heart Rate/drug effects
- Longevity/drug effects
- Pericardial Effusion/chemically induced
- Pericardial Effusion/embryology
- Pericardial Effusion/pathology
- RNA, Messenger/metabolism
- Teratogens/toxicity*
- Zebrafish
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- PubMed
- 18470470 Full text @ Bull. Environ. Contam. Toxicol.
- CTD
- 18470470
Citation
Wu, Y.D., Jiang, L., Zhou, Z., Zheng, M.H., Zhang, J., and Liang, Y. (2008) CYP1A/Regucalcin Gene Expression and Edema Formation in Zebrafish Embryos Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Bulletin of environmental contamination and toxicology. 80(6):482-486.
Abstract
In this study, zebrafish eggs were exposed to a relatively low concentration (50 pg/mL) of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) for 72 h and then transferred to vehicle/TCDD-free water for the remainder of the experiments. Mortality, heart rates, edema severity, CYP1A, and regucalcin gene expressions were investigated to study TCDD-induced toxicity in zebrafish during the early life stage. Results indicated that the 50 pg/mL TCDD caused severe and visible developmental toxicity. Further research of the long term and low concentration of TCDD exposure is required.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping