PUBLICATION
Developmental expression patterns of the zebrafish small heat shock proteins
- Authors
- Marvin, M., O'Rourke, D., Kurihara, T., Juliano, C.E., Harrison, K.L., and Hutson, L.D.
- ID
- ZDB-PUB-080102-4
- Date
- 2008
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 237(2): 454-463 (Journal)
- Registered Authors
- Hutson, Lara
- Keywords
- alpha-crystallin, heat shock, somite, heart, lens, mid-hindbrain boundary, notochord
- MeSH Terms
-
- Animals
- Gene Expression Profiling
- Gene Expression Regulation, Developmental/physiology*
- Heat-Shock Proteins, Small/metabolism*
- In Situ Hybridization
- Reverse Transcriptase Polymerase Chain Reaction
- Zebrafish/embryology*
- Zebrafish/metabolism
- PubMed
- 18161059 Full text @ Dev. Dyn.
Citation
Marvin, M., O'Rourke, D., Kurihara, T., Juliano, C.E., Harrison, K.L., and Hutson, L.D. (2008) Developmental expression patterns of the zebrafish small heat shock proteins. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(2):454-463.
Abstract
Small heat shock proteins (sHSPs), or alpha-crystallins, are low-molecular weight proteins found in every kingdom and nearly every species examined to date. Many, if not all, sHSPs act as molecular chaperones. Several also have functions independent of their chaperone activity, and at least a few are expressed in specific spatiotemporal patterns during embryonic and/or juvenile stages, suggesting specific roles during development. To date, however, no one has systematically characterized the expression patterns of all of the sHSPs during development in any organism. We have characterized the normal heat shock-induced expression patterns of all 13 zebrafish sHSPs during development. Seven of the sHSPs are expressed in a tissue-specific manner during development, and five are upregulated by heat shock. The results of these studies provide a foundation for analysis of sHSP function during normal development and their roles in protecting cells from the effects environmental stressors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping