PUBLICATION
Pax proteins and eye development
- Authors
- Macdonald, R., and Wilson, S.W.
- ID
- ZDB-PUB-061221-1
- Date
- 1996
- Source
- Current opinion in neurobiology 6(1): 49-56 (Review)
- Registered Authors
- Macdonald, Rachel, Wilson, Steve
- Keywords
- none
- MeSH Terms
-
- Animals
- Eye/growth & development*
- Genes/genetics*
- Humans
- Models, Neurological
- Mutation
- Phenotype
- Transcription Factors/genetics*
- PubMed
- 8794051 Full text @ Curr. Opin. Neurobiol.
Citation
Macdonald, R., and Wilson, S.W. (1996) Pax proteins and eye development. Current opinion in neurobiology. 6(1):49-56.
Abstract
Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions. The genetic cascade triggered by eyeless leads to eye formation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages of eye development. A second vertebrate Pax gene, pax-2, is also required during eye development and appears to play a role during closure of the choroid fissure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping