PUBLICATION
Defining the origins and evolution of the chemokine/chemokine receptor system
- Authors
- Devries, M.E., Kelvin, A.A., Xu, L., Ran, L., Robinson, J., and Kelvin, D.J.
- ID
- ZDB-PUB-051221-8
- Date
- 2006
- Source
- Journal of immunology (Baltimore, Md. : 1950) 176(1): 401-415 (Journal)
- Registered Authors
- Robinson, Judith
- Keywords
- none
- MeSH Terms
-
- Animals
- Chemokines/genetics*
- Evolution, Molecular
- Humans
- Molecular Sequence Data
- Phylogeny*
- Receptors, Chemokine/genetics*
- Sequence Analysis, Protein
- Sequence Homology, Amino Acid
- PubMed
- 16365434 Full text @ J. Immunol.
Citation
Devries, M.E., Kelvin, A.A., Xu, L., Ran, L., Robinson, J., and Kelvin, D.J. (2006) Defining the origins and evolution of the chemokine/chemokine receptor system. Journal of immunology (Baltimore, Md. : 1950). 176(1):401-415.
Abstract
The chemokine system has a critical role in mammalian immunity, but the evolutionary history of chemokines and chemokine receptors are ill-defined. We used comparative whole genome analysis of fruit fly, sea urchin, sea squirt, pufferfish, zebrafish, frog, and chicken to identify chemokines and chemokine receptors in each species. We report 127 chemokine and 70 chemokine receptor genes in the 7 species, with zebrafish having the most chemokines, 63, and chemokine receptors, 24. Fruit fly, sea urchin, and sea squirt have no identifiable chemokines or chemokine receptors. This study represents the most comprehensive analysis of the chemokine system to date and the only complete characterization of chemokine systems outside of mouse and human. We establish a clear evolutionary model of the chemokine system and trace the origin of the chemokine system to approximately 650 million years ago, identifying critical steps in their evolution and demonstrating a more extensive chemokine system in fish than previously thought.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping