PUBLICATION
Sarcoglycans of the zebrafish: orthology and localization to the sarcolemma and myosepta of muscle
- Authors
- Chambers, S.P., Anderson, L.V., Maguire, G.M., Dodd, A., and Love, D.R.
- ID
- ZDB-PUB-030408-16
- Date
- 2003
- Source
- Biochemical and Biophysical Research Communications 303(2): 488-495 (Journal)
- Registered Authors
- Chambers, Steve, Dodd, Andrew, Love, Donald R., Maguire, Giselle
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Cytoskeletal Proteins/analysis
- Cytoskeletal Proteins/chemistry
- Cytoskeletal Proteins/metabolism*
- Dystroglycans
- Humans
- Immunohistochemistry
- Membrane Glycoproteins/analysis
- Membrane Glycoproteins/chemistry
- Membrane Glycoproteins/metabolism*
- Molecular Sequence Data
- Muscle Proteins/analysis
- Muscle Proteins/chemistry
- Muscle Proteins/metabolism*
- Muscle, Skeletal/metabolism*
- Muscle, Skeletal/ultrastructure
- Phylogeny
- Sarcolemma/metabolism
- Sarcolemma/ultrastructure*
- Sequence Alignment
- Sequence Homology, Amino Acid
- Zebrafish
- PubMed
- 12659844 Full text @ Biochem. Biophys. Res. Commun.
Citation
Chambers, S.P., Anderson, L.V., Maguire, G.M., Dodd, A., and Love, D.R. (2003) Sarcoglycans of the zebrafish: orthology and localization to the sarcolemma and myosepta of muscle. Biochemical and Biophysical Research Communications. 303(2):488-495.
Abstract
The zebrafish is an established model of vertebrate development and is also receiving increasing attention in terms of human disease modelling. In order to provide experimental support to realize this modelling potential, we report here the identification of apparent orthologues of many critical members of the dystrophin-associated glycoprotein complex (DGC) that have been implicated in a diverse range of neuromuscular disorders. In addition, immunohistochemical studies show the localization of the DGC to the sarcolemma of adult zebrafish muscle and in particular the myosepta. Together, these data suggest that the DGC in adult zebrafish may play a highly conserved functional role in muscle architecture that, when disrupted, could offer insight into human neuromuscular disease processes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping