PUBLICATION
The zebrafish as a tool for understanding the biology of visual disorders
- Authors
- Goldsmith, P. and Harris, W.A.
- ID
- ZDB-PUB-030115-10
- Date
- 2003
- Source
- Seminars in cell & developmental biology 14(1): 11-18 (Review)
- Registered Authors
- Harris, William A.
- Keywords
- Disease; Retina; Retinal; Vision; Zebrafish
- MeSH Terms
-
- Animals
- Blindness/etiology
- Clinical Laboratory Techniques
- Models, Animal
- Retina/anatomy & histology
- Retina/pathology
- Retinal Degeneration/etiology
- Vision Disorders/etiology*
- Vision Disorders/genetics
- Vision Disorders/pathology
- Zebrafish/genetics
- Zebrafish/physiology*
- PubMed
- 12524002 Full text @ Sem. Cell Dev. Biol.
Citation
Goldsmith, P. and Harris, W.A. (2003) The zebrafish as a tool for understanding the biology of visual disorders. Seminars in cell & developmental biology. 14(1):11-18.
Abstract
Retinal degenerations are the commonest cause of blindness in the Western world, affecting 5% of the population, yet remain largely untreatable. A better understanding of the mechanisms of disease is needed. Zebrafish fill a gap in the current repertoire of models, offering genetic tractability in a vertebrate. Their retina has many similarities with a human retina. Importantly, unlike rodents, they have rich colour vision, offering the potential to model the macular degenerations. A variety of physiological assays, genetic manipulations and histological tools have been developed and useful models of human disease created.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping