PUBLICATION

Stat3 controls cell movements during zebrafish gastrulation

Authors
Yamashita, S., Miyagi, C., Carmany-Rampey, A., Shimizu, T., Fujii, R., Schier, A.F., and Hirano, T.
ID
ZDB-PUB-020301-1
Date
2002
Source
Developmental Cell   2(3): 363-375 (Journal)
Registered Authors
Carmany-Rampey, Amanda, Fujii, Ritsuko, Miyagi, Chiemi, Schier, Alexander, Shimizu, Takashi, Yamashita, Susumu
Keywords
none
MeSH Terms
  • Animals
  • Body Patterning/physiology
  • Cell Movement/physiology*
  • Cytoskeletal Proteins/metabolism
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/metabolism*
  • Gastrula/cytology*
  • Gastrula/physiology*
  • Gene Expression Regulation, Developmental
  • Mesoderm/cytology
  • Molecular Sequence Data
  • Organizers, Embryonic/physiology
  • Proto-Oncogene Proteins/metabolism
  • STAT3 Transcription Factor
  • Stem Cells/cytology
  • Trans-Activators/genetics*
  • Trans-Activators/metabolism*
  • Wnt Proteins
  • Zebrafish
  • Zebrafish Proteins*
  • beta Catenin
(all 21)
PubMed
11879641 Full text @ Dev. Cell
Abstract
Vertebrate axis formation requires both the correct specification of cell fates and the coordination of gastrulation movements. We report that the zebrafish signal transducer and activator of transcription 3 (Stat3) is activated on the dorsal side by the maternal Wnt/-catenin pathway. Zebrafish embryos lacking Stat3 activity display abnormal cell movements during gastrulation, resulting in a mispositioned head and a shortened anterior-posterior axis, but show no defects in early cell fate specification. Time course analysis, cell tracing, and transplantation experiments revealed that Stat3 activity is required cell autonomously for the anterior migration of dorsal mesendodermal cells and non-cell autonomously for the convergence of neighboring paraxial cells. These results reveal a role for Stat3 in controlling cell movements during gastrulation.
Genes / Markers
Marker Marker Type Name
stat3GENEsignal transducer and activator of transcription 3 (acute-phase response factor)
1 - 1 of 1
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Figures
No images available
Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
Target Reagent Reagent Type
stat3MO1-stat3MRPHLNO
1 - 1 of 1
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Fish
No data available
Antibodies
Orthology
Engineered Foreign Genes
No data available
Mapping
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Citation
Yamashita, S., Miyagi, C., Carmany-Rampey, A., Shimizu, T., Fujii, R., Schier, A.F., and Hirano, T. (2002) Stat3 controls cell movements during zebrafish gastrulation. Developmental Cell. 2(3):363-375.