PUBLICATION

Zebrafish frizzled-2 morphant displays defects in body axis elongation

Authors

Sumanas, S., Kim, H.J., Hermanson, S., and Ekker, S.C.

ID

ZDB-PUB-010807-16

Date

2001

Source

Genesis (New York, N.Y. : 2000) 30(3): 114-118 (Journal)

Registered Authors

Keywords

none

MeSH Terms

(all 21)

PubMed

11477686 Full text @ Genesis

Abstract

Genes / Markers

Marker	Marker Type	Name
dlx4a	GENE	distal-less homeobox 4a
foxa1	GENE	forkhead box A1
fzd2	GENE	frizzled class receptor 2
hoxb9a	GENE	homeobox B9a
myod1	GENE	myogenic differentiation 1
sox9a	GENE	SRY-box transcription factor 9a
tbxta	GENE	T-box transcription factor Ta
z22516	SSLP	Z22516

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Figures

Expression

Phenotype

Fish	Conditions	Stage	Phenotype	Figure
WT + MO2-fzd2	standard conditions	5-9 somites	notochord decreased length, abnormal	Fig. 2
WT + MO2-fzd2	standard conditions	5-9 somites	notochord increased thickness, abnormal	Fig. 2
WT + MO2-fzd2	standard conditions	5-9 somites	notochord undulate, abnormal	Fig. 2
WT + MO2-fzd2	standard conditions	5-9 somites	somite condensed, abnormal	Fig. 2
WT + MO2-fzd2	standard conditions	5-9 somites	somite increased width, abnormal	Fig. 2
WT + MO2-fzd2 + MO3-fzd2	standard conditions	Shield	convergent extension involved in gastrulation disrupted, abnormal	Fig. 2
WT + MO2-fzd2 + MO3-fzd2	standard conditions	Shield	whole organism oblong, abnormal	Fig. 2
WT + MO2-fzd2 + MO3-fzd2	standard conditions	10-13 somites	notochord undulate, abnormal	Fig. 2
WT + MO2-fzd2 + MO3-fzd2	standard conditions	10-13 somites	somite increased width, abnormal	Fig. 2
WT + MO2-fzd2 + MO3-fzd2	standard conditions	10-13 somites	whole organism anterior-posterior axis decreased length, abnormal	Fig. 2

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Mutations / Transgenics

Allele	Construct	Type	Affected Genomic Region
hi1134Tg	Tg(nLacz-GTvirus)	Transgenic Insertion	sox9a

Human Disease / Model

Sequence Targeting Reagents

Target	Reagent	Reagent Type
fzd2	MO2-fzd2	MRPHLNO
fzd2	MO3-fzd2	MRPHLNO

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping