Person
Wang, Han
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Biography and Research Interest
Most organisms display daily changes at molecular, cellular, physiological, and behavioral levels, which are known as circadian rhythms. The circadian clock controls fundamental life processes such as the human sleep-wake cycle. Many human sleep disorders and dysrhythmias are thought to result from circadian defects. A full molecular genetic understanding of circadian rhythmicity is critical for diagnosis, prevention and treatment of human dysrhythmias. We study molecular genetic mechanisms underlying zebrafish circadian rhythmicity. Using TALEN and CRISPR/Cas9 techniques, we have generated a number of mutants for zebrafish circadian clock genes. The roles of these circadian clock genes in the circadian system and life processes are investigated.
We also used zebrafish to study a group of human diseases called porphyria, derived from defective enzymes in heme biosynthesis. We have established several zebrafish models for human porphyria. We are interested in studying novel aspects of porphyria pathogenesis.
We also used zebrafish to study a group of human diseases called porphyria, derived from defective enzymes in heme biosynthesis. We have established several zebrafish models for human porphyria. We are interested in studying novel aspects of porphyria pathogenesis.
Non-Zebrafish Publications
Wang, H., E. D. McArthur, and D. C. Freeman. 1999. Narrow hybrid zone between two subspecies of big sagebrush (Artemisia tridentata: Asteraceae). IX. Elemental uptake and niche differentiation. American Journal of Botany 86:1099-1107.Freeman, D. C., H. Wang, S. C. Sanderson, and E. D. McArthur. 1999. Characterization of a narrow hybrid zone between two subspecies of big sagebrush (Artemisia tridentata: Asteraceae). VII. Demographic and community analysis. Evolutionary Ecology Research 1:487-502.
J. H. Graham, D. C. Freeman, H. Wang, and E. D. McArthur. 1999. Ecological analysis of the big sagebrush hybrid zone. In: McArthur, E. D.; Ostler, W. K.; Wambolt, C. L., comps. Proceedings: Shrub Ecotones, 1998 August 12-14, Ephraim, UT Proceedings RMRS-P-11, pages 11-14. Ogden, UT: U. S. Department of Agriculture, Forest Service, Rocky Mountain Research Station.
D. C. Freeman, K. J. Miglia, E. D. McArthur, J. H. Graham, and H. Wang.1999. Narrow Hybrid Zone Between Two Subspecies of Big Sagebrush (Artemisia tridentata: Asteraceae): X. Performance in Reciprocal Transplant Gardens. In: McArthur, E. D.; Ostler, W. K.; Wambolt, C. L., comps. Proceedings: Shrub Ecotones, 1998 August 12-14, Ephraim, UT Proceedings RMRS-P-11, pages 15-24. Ogden, UT: U. S. Department of Agriculture, Forest Service, Rocky Mountain Research Station.
Wang, H., D. W. Byrd, J. L. Howard, E. D. McArthur, J. H. Graham, and D. C. Freeman. 1998. Narrow hybrid zone between two subspecies of big sagebrush (Artemisia tridentata: Asteraceae). V. Soil properties. International Journal of Plant Sciences 159:139-147.
McArthur, E. D., D. C. Freeman, J. H. Graham, H. Wang, S. C. Sanderson, and B. N. Smith. 1998. Narrow hybrid zone between two subspecies of big sagebrush (Artemisia tridentata: Asteraceae). VI. Respiration and water potential. Canadian Journal of Botany 76:567-574.
Byrd, D. W., E. D. McArthur, H. Wang, and D. C. Freeman. 1998. Narrow hybrid zone between two subspecies of big sagebrush (Artemisia tridentata: Asteraceae). VIII. Temporal and spatial patterns of terpenes. Biochemical Systematics and Ecology 27:11-25.
Wang, H., E. D. McArthur, S. C. Sanderson, J. H. Graham, and D. C. Freeman. 1997. Narrow hybrid zone between two subspecies of big sagebrush (Artemisia tridentata: Asteraceae). IV. Reciprocal transplant experiments. Evolution 51:95-102.