Person

Trede, Nick

Person ID: ZDB-PERS-971016-20
Email: nikolaus.trede@hci.utah.edu
URL: http://www.huntsmancancer.org/research/labs/trede-lab
Affiliation: Trede Lab
Address: Huntsman Cancer Insitute Suite 4265 2000, Circle of Hope Salt Lake City, UT 84112 USA
Country: United States
Phone: 801-585-0199 (O) 801-587-3054 (L)
Fax: 801-585-5470
ORCID ID

Biography and Research Interest

EDUCATION

A. Baccalaureate Degree: not awarded in German system. Finished pre-med studies at Albert Ludwigs University Medical School, Freiburg in 7/1982

B. Advanced Degrees: 12/1987, Albert Ludwigs University Medical School, Freiburg, MD; 12/1992, Université Paris VII, PhD in immunology

C. Pediatric internship, 7/1993-6/1994, Children's Hospital, Boston
Junior Assistant Resident in Pediatrics, 7/1994-6/1995, Children's Hospital, Boston
Clinical Fellow in Pediatric Hematology/Oncology, 7/1995-6/1998, Children's Hospital/DFCI, Boston

D. Specialty and Sub-specialty Board Certifications:
Pediatrics: 1998
Pediatric Hematology/Oncology: 2000

E. Postdoctoral (Ph.D.) Fellowships: through 6/2004, Children's Hospital,
Boston, laboratory of Len Zon, funded through K08

PROFESSIONAL EXPERIENCE

7/1998-6/2004: Pediatric Hematology/Oncology
Attending Physician for inpatient and outpatient services at Children's Hospital and DFCI, Boston
Instructor in Pediatrics, Harvard Medical School

Since 7/2004: Assistant Professor in Pediatrics, University of Utah
Adjunct Assistant Professor in Oncologic Sciences

RESEARCH INTERESTS

My lab is interested in modeling human diseases of the immune system in zebrafish. These diseases include immunodeficiency (such as DiGeorge syndrome and SCID), autoimmunity and leukemia.
We are also involved in exploring the innate immune system using a transgenic approach in zebrafish.

Publications

Non-Zebrafish Publications

1. Trede, N.S., R. Urbanek, G. Burow, U. Wais: Vorfelddiagnostik zur Erfassung von Patienten mit Allergien der Atemwege. Helv. paediat. Acta 41, 243 (1986)
2. Otto,J. R. Urbanek, G. Burow, N. Trede, B. Müller: in-vitro Suchtest für die Diagnose von Allergien auf inhalative und nutritive Allergene. Mschr. Kinderheilkd. 134, 631 (1986)
3. Trede, N.S., R. Urbanek, G. Burow, J. Otto : Serological screening for allergy to inhalants by multi-allergen-radioimmunoassay. Helv. paediat. Acta 42, 129 (1987)
4. Trede, N.S., R. Urbanek : Combination of parenteral and oral immunotherapy in grass -pollenallergic children. A double-blind controlled study of clinical and immunological efficacy. Allergy 44, 272 (1989)
5. Jouvin-Marche, E., N.S. Trede, A. Bandeira, A. Tomas, D.Y. Loh, P.A. Cazenave : Different large deletions of T cell receptor V beta genes in natural populations of mice. Eur. J. Immunol. 19, 1921 (1989)
6. Jouvin-Marche, E., M.G. Morgado, N.S. Trede, P.N. Marche, D. Couez, I. Hue, C. Gris, M. Malissen, P.A. Cazenave : Complexity, polymorphism, and recombination of mouse T-cell receptor alpha gene families. Immunogenetics 30, 99 (1989)
7. Trede, N.S, R.S. Geha, T. Chatila : Transcriptional activation of IL-1<= and TNF-± genes by MHC class II ligands. J. Immunol. 146, 2310 (1991)
8. Scholl, P.R., N. Trede, T.A. Chatila, R.S. Geha: The role of tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. J. Immunol. 148, 2237 (1992)
9. Trede, N.S., E. Castigli, R.S. Geha, T.A. Chatila: Microbial superantigens induce NF-?B in human monocytic cells. J. Immunol. 150, 5604 (1993)
10. Trede, N.S., P.R. Scholl, R.S. Geha, T.A. Chatila: Early activation events induced by the staphylococcal superantigen toxic-schock syndrome toxin-1 in human peripheral blood monocytes. Clin. Immunol. Immunopathol. 70, 137-144 (1994).
11. Fuleihan, R., N.S. Trede, T. Chatila, R.S. Geha: Superantigens activate HIV-1 gene expression in monocytes. Clin. Immunol. Immunopathol. 72, 357 (1994)
12. Trede, N.S., T.A. Chatila, R.S. Geha: Induction of activator protein-1 (AP-1) by staphylococcal superantigens in human monocytic cells. Europ. J. Immunol. 23, 2129 (1993)
13. Trede, N.S., A.V. Tsytsykova, A.E. Goldfeld, T. Chatila, R.S. Geha: Transcriptional activation of the human TNF-_ promoter by the microbial superantigen SEA in human monocytic cells. J. Immunol. 155, 902 (1995)
14. Trede, N.S., A.B.Warwick, P.M. Rosoff, B.E. Bierer, R. Rohrer, E.C. Guinan: Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. Bone Marrow Transplantation, 20, 257 (1997)
15. Marler JJ, Rubin JB, Trede NS, Connors S, Grier H, Upton J, Mulliken JB, Folkman J.: Successful antiangiogenic therapy of giant cell angioblastoma with interferon alfa 2b: report of 2 cases. Pediatrics. 109, E37 (2002)

Reviews:
Urbanek, R., N.S. Trede : Orale Hyposensibilisierung. Fortschr. Med. 105, 415 (1987)
Chatila, T., P. Scholl, F. Spertini, N. Trede, R. Fuleihan, R.S. Geha : Toxic shock syndrome toxin-1, toxic shock and the immune system. Current Topics Microb. Immunol. 174, 63-80 (1991).
Chatila, T., P. Scholl, N. Ramesh, N. Trede, R. Fuleihan, T. Morio, R.S. Geha : Cellular and molecular mechanisms of immune activation by microbial superantigens: Studies using Toxic Shock Syndrome Toxin-1. Chem. Immunol. 55 , 146 (1992).