Biography and Research Interest

Publications

Non-Zebrafish Publications

BUHLER, D.R., YANG, Y.-H., DREHER, T.W., MIRANDA, C.L. and WANG, J.-L. (1994). Cloning, sequencing, and expression of the major rainbow trout constitutive cytochrome P450 (CYP2K1). Identification of a new cytochrome P450 gene subfamily. Arch. Biochem. Biophys.312, 45-51.

BUHLER, D.R., WANG, J.-L., ZHAO, X., REED, R.L., HENDERSON, M.L. and MIRANDA, C.L. (1995). The effects of a luteinizing hormone-releasing hormone analogue on cytochrome P450 in rainbow trout. Mar. Environ. Res. 39, 93-96.

TAKAHASHI, N., MIRANDA, C.L., HENDERSON, M.C., BUHLER, D.R., WILLIAMS, D.E. and BAILEY, G.S. (1995). Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A1 inhibitors: -naphthoflavone, -naphthoflavone and trout CYP1A1 peptide antibody. Comp. Biochem. Physiol. Pharmacol. Toxicol. 110, 273-280.

CELANDER, M., BUHLER, D.R., FORLIN, L., GOKSOYR, A., MIRANDA, C.L., WOODIN, B.R. and STEGEMAN, J.J. (1996). Immunochemical relationships of cytochrome P4503A-like proteins in teleost fish. Fish Physiol. Biochem. 15, 323-332.

MIRANDA, C.L., HENDERSON, M.C., WILLIAMS, D.E. and BUHLER, D.R. (1997). In vitrometabolism of 7,12-dimethylbenz[a]anthracene by rainbow trout liver microsomes and trout P450 isoforms. Toxicol. Appl. Pharmacol. 142, 123-132.

WANG-BUHLER, J.-L., ZHAO, X., YANG, Y-H., MIRANDA, C.L. and BUHLER, D.R. (1997) Expression of a constitutive cytochrome P450 (CYP2K1) in livers of rainbow trout (Oncorhynchus mykiss) embryo and sac-fry. Aquatic Toxicol. 37, 237-251.

GOONERATNE, R., MIRANDA, C.L., HENDERSON, M.C. and BUHLER, D.R. (1997). Purification of two CYP1A proteins from BNF-treated rainbow trout. Xenobiotica 27, 175-187.

BUHLER, D.R., MIRANDA, C.L., DEINZER, M.L., GRIFFIN, D.A. and HENDERSON, M.C. (1997). The regiospecific hydroxylation of lauric acid by rainbow trout (Oncorhynchus mykiss) cytochrome P450s. Drug Metab. Dispos. 25, 1176-1183.

SCHLENK, S., EL-ALFY, A. and BUHLER, D.R. (1997). Down regulation of hepatic flavin- containing monooxygenase activity by 17 -estradiol in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. 118C, 199-202.

MIRANDA, C.L., HENDERSON, M.C. and BUHLER, D.R. (1998). Evaluation of chemicals as inhibitors of trout cytochrome P450s. Toxicol. Appl. Pharmacol. 148, 237-244.

COK, I., WANG-BUHLER, J.-L., KEDZIERSKI, M.M., MIRANDA, C.L., YANG, Y.-H. and BUHLER, D.R. (1998). Expression of CYP2M1, CYP2K1 and CYP3A27 in brain , blood, small intestine and other tissues of rainbow trout. Biochem. Biophys. Res. Commun.244, 790-795.

YANG, Y.-H., WANG, J.-L., MIRANDA, C.L. and BUHLER, D.R. (1998). CYP2M1: cloning, sequencing and expression of a new cytochrome P450 from rainbow trout liver with fatty acid ( -6)-hydroxylation activity. Arch. Biochem. Biophys. 352, 271-280.

WILLIAMS, D.E., LECH, J.J. and BUHLER, D.R. (1998). Xenobiotics and xenoestrogens in fish: Modulation of cytochrome P450 and carcinogenesis. Mutation Res. 399, 179-192.

HAASCH, M.L., HENDERSON, M.C. and BUHLER, D.R. (1998). Induction of lauric acid hydroxylase activity in catfish and bluegill by peroxisome proliferating agents. Compr. Biochem. Physiol. 121C, 297-303.

HAASCH, M.L., HENDERSON, M.C. and BUHLER, D.R. (1998). Induction of CYP2M1 and CYP2K1 lauric acid hydroxylases activities by peroxisome proliferating agents in certain fish species: Possible implications. Mar. Environ. Res. 46, 37-40.

BUHLER, D.R. and WANG-BUHLER, J.-L. (1998). Rainbow trout cytochrome P450s: Purification, molecular aspects, metabolic activity, induction and role in environmental monitoring. Comp. Biochem. Physiol. Part C 121, 107-137.

LEE, S.-J., WANG-BUHLER, J.-L., COK, I., YU, T.S., YANG, Y.-H., MIRANDA, C.L., LECH, J.J. and BUHLER, D.R. (1998). Cloning, sequencing and tissue expression of CYP3A27, a new member of the CYP3A subfamily from embryonic and adult rainbow trout livers. Arch. Biochem. Biophys. 360, 53-61.

DONOHOE, R.M., WANG-BUHLER, J.-L., BUHLER, D.R. and CURTIS, L.R. (1999). Comparative response of cytochrome P4501A and estrogen-induced vitellogenesis to 3,3',4,4',5,5'-hexachlorobiphenyl in rainbow trout (Oncorhynchus mykiss). Environ. Toxicol. and Chem. 18, 1046-1052.

BUHLER, D.R., MIRANDA, C.L., HENDERSON, M.C., YANG, Y.-H., LEE, S.-J., and WANG- BUHLER, J.-L. (2000) Effects of 17 -estradiol and testosterone on hepatic mRNA/protein levels and catalytic activities of CYP2K1, CYP2M1 and CYP3A27 in rainbow trout (Oncorhynchus mykiss). Toxicol. Appl. Pharmacol. 168, 91-101.

YANG, Y.-H., MIRANDA, C. L., HENDERSON, M.C., WANG-BUHLER, J.-L. and BUHLER, D.R. (2000). Heterologous expression of CYP2K1 and identification of the expressed protein (BV-CYP2K1) as lauric acid ( -1) hydroxylase and aflatoxin B1 exo-epoxidase. Drug Metab. Dispos. 28, 1279-1283.