Person
Clarke, Jon
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Biography and Research Interest
We are interested in the morphogenesis and regionalisation of the neural tube, the development of the neuroepithelium especially in terms of its apico-basal organisation and the way that neural progenitors generate the differentiated cell types of the brain. We use a variety of cell labeling techniques and live-imaging that allow us to follow the fate of either individual cells or populations of cells. In addition we are using calcium imaging and FRAP techniques to study cell-cell communication in the early neuroepithelium.
Non-Zebrafish Publications
Recent nonzebrafish publications:Clarke, J.D.W. & Lumsden, A. (1993). Segmental repetition of neuronal phenotype sets in the chick embryo hindbrain. Development 118, 151-162.
Lumsden, A., Clarke, J.D.W., Keynes, R. & Fraser, S. E. (1994). Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain. Development 120, 1581-1589.
Gale, E., Prince, V., Lumsden, A., Clarke, J., Holder, N. & Maden, M. (1996). Late effects of retinoic acid on neural crest and aspects of rhombomere identity. Development 122, 783-793.
Cohn, M.J., Patel, K., Krumlauf, R., Wilkinson, D.G., Clarke, J.D.W. and Tickle, C. (1997). Hox9 genes and vertebrate limb specification. Nature 387, 97-101.
Vargesson, N., Clarke, J.D.W., Vincent, K., Coles, C., Wolpert, L. and Tickle, C. (1997). Cell fate in the chick limb bud and its relationship to gene expression. Development 124, 1909-1918.
Nittenberg, R., Patel, K., Joshi, Y., Krumlauf, R., Wilkinson, D. G., Brickell, P.M., Tickle, C. and Clarke, J.D.W. (1997). Cell movements, neuronal organisation and gene expression in hindbrains lacking morphological boundaries. Development 124, 2297-2306.
Yang, Y., Drossopoulou, G., Chuang, P.-T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J., Niswander, L., McMahon, A. and Tickle, C. (1997). Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of antero-posterior polarity in the chick limb. Development 124, 4393-4404.
Altabef, M., Clarke, J.D.W. and Tickle, C. (1997). Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb. Development 124, 4547- 4556.
Kostakopoulou, K., Vargesson, N., Clarke, J.D.W., Brickell, P.M. and Tickle, T. (1997). Local origin of cells in FGF-4-induced outgrowth of amputated chick wing bud stumps. Int. J. Dev. Biol. 41, 747-750.
Clarke, J.D.W., Erskine, L. and Lumsden, A. (1998). Differential progenitor dispersal and the spatial origin of early neurons can explain the predominance of single-phenotype clones in the chick hindbrain Developmental Dynamics 212, 14-26.
McGonnell, I.M., Clarke, J.D.W. and Tickle, C. (1998). Fate map of the developing chick face: Analysis of expansion of facial primardia and establishment of the primary palate. Developmental Dynamics 212, 102-118.
Hunt, P., Clarke, J.D.W., Buxton, P., Ferretti, P. and Thorogood, P. (1998). Stability and plasticity of neural crest patterning and branchial arch Hox code after extensive cephalic crest migration. Developmental Biology 198, 82-104.
Erskine, L., Patel, K. and Clarke, J.D.W. (1998). Progenitor dispersal and the origin of early neuronal phenotypes in the chick embryo spinal cord. Developmental Biology 199, 26-41.
Meyer, M., Clarke, J.D.W., Patel, K., Townsend-Nicholson, A. and Burnstock, G. (1999). Selective expression of a purinoreceptor, cP2Y1, suggests a role for nucleotide signalling in development of the chick embryo. Developmental Dynamics 214, 152-158.
Dale, K. Sattar, N., Heemskerk, J., Clarke, J.D.W., Placzek, M. and Dodd, J. (1999). Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin. Development 126, 397-408.
Clarke, J.D.W. and Tickle, C. (1999). Fatemaps old and new. Nature Cell Biology 1, E103-E109.
Zhang, F., Clarke, J.D.W. and Ferretti, P. (2000) FGF-2 up-regulation and proliferation of neural progenitors in the regenerating amphibian spinal cord in vivo. Developmental Biology 225, 381-391