Person

Clark, Karl

Person ID
ZDB-PERS-960905-4
Email
kjclark@mac.com
URL
Affiliation
Clark Lab
Address
Mayo Clinic Cancer Center Dept. Biochemistry and Molecular Biology 200 1st St S Guggenheim 1321A Rochester, MN 55905 USA
Country
United States
Phone
507-538-5311
Fax
ORCID ID
0000-0002-9637-0967
Biography and Research Interest
My lab, the Behavioral and Functional Genetics Laboratory at Mayo Clinic, is built upon my interest and long history of technology development and genome engineering. I collaborate with a large array of scientists with whom I work to develop new methods of gene editing, and my lab focuses on deployment in zebrafish. We apply these molecular and genetic tools to dissect and discover the interactions between genes and the environment that affect both short and long-term changes in physiology and behavior. We have developed zebrafish assays and genetic tools to identify modifiers of hypothalamic-pituitary-adrenal (interrenal) stress responses looking at both rapid (non-genomic) and delayed (genomic) responses to stressors. Our expertise in both gene editing and behavioral genetics have made us an ideal partner to work with the Center for Individualized Medicine’s Translational Omics Program to functionally test patient variants using diverse biological assays and models to assess potential for pathogenicity in a wide variety of rare disorders. In the next five to ten years, we will move beyond diagnostics by taking advantage of gene editing tools and animal models to develop new therapeutics for rare disease.
Publications
Non-Zebrafish Publications
A complete listing of my publications can be found on my NCBI Bibliography (https://www.ncbi.nlm.nih.gov/sites/myncbi/karl.clark.1/bibliography/42584231/public/?sort=date&direction=descending)