Person
Carvan III, Michael J.
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Biography and Research Interest
The primary interests of the laboratory involve xenobiotic-inducible genes, their mechanism(s) of regulation, and their function in normal cellular physiology. Current emphasis is on 1) the developmental effects of ethanol, persistent chemical pollutants like dioxin and mercury, and neurotoxic pesticides; 2) receptor-dependent interactions with DNA response elements (especially those that respond to metals, aromatic hydrocarbons, and oxidative stress)and their role in transcriptome responses; and 3) identification of genes that influence sensitivity and resistance to the effects of environmental chemicals.
Non-Zebrafish Publications
Nebert, D.W., T.P. Dalton, G.W. Stuart and M.J. Carvan III. 2000. 'Gene-swap knock-in' cassette in mice to study allelic differences in human genes. Annals of the New York Academy of Science, 919:148-170.Carvan, M.J.,III, L.V. Ponomareva, W.A. Solis, R.S. Matlib, A. Puga, and D.W. Nebert. 1999. Trout CYP1A3 gene: recognition of fish DNA motifs by mouse regulatory proteins. Marine Biotechnology 1:155-166.
Nebert, D.W. and M.J. Carvan III. 1997. Ecogenetics: From Ecology to Health. Toxicology and Industrial Health 13:1-31.
Flood, L.P., M.J. Carvan III, L. Yeager, and D. L. Busbee. 1996. Reduction in hepatic microsomal P-450 and related catalytic activity in farm-raised red drum. Journal of Aquatic Animal Health 8:13-21.
Alterman, M.A., M.J. Carvan and D.L. Busbee. 1995. Dose-dependent induction of the microsomal monooxygenase system by phenobarbital and 3-methylcholanthrene in ad libitum and calorie restricted female rats. Xenobiotica 25:17-26.
Carvan, M.J.,III, L.P. Flood, B. D. Campbell, and D.L. Busbee. 1995. Effects of benzo(a)pyrene on fetal dolphin kidney epithelial cells: Inhibition of proliferation and initiation of DNA damage. Chemosphere 30:187-198.
Alterman, M.A., M.J. Carvan and D.L. Busbee. 1994. Ethoxyresorufin and pentoxyresorufin O-dealkylation by hepatic microsomes from female Fisher 344 rats: effects of age and diet. Mechanisms of Aging and Development 77:1-11.
Carvan, M.J.,III, M. Santostefano, S. Safe and D.L. Busbee. 1994. Characterization of a bottlenose dolphin (Tursiops truncatus) kidney epithelial cell line. Marine Mammal Science 10:52-69.
Alterman, M.A., V.K. Srivastava, M.J. Carvan, J. Leakey, R. Hart and D.L. Busbee. 1993. Effects of aging and long term caloric restriction on hepatic microsomal monooxygenases in female Fisher 344 rats: alterations in the basal cytochrome P-450 catalytic activities. AGE, J. American Aging Association 16:1-8.