Person

Paw, Barry (Deceased)

Person ID
ZDB-PERS-960805-432
URL
http://paw-lab.bwh.harvard.edu
Affiliation
Paw Lab
Address
Division of Hematology-Oncology Department of Medicine Brigham and Women's Hospital and Boston Children's Hospital Harvard Medical School 77 Avenue Louis Pasteur HIM Building, Room 616 Boston, MA 02115-5727 USA
Country
United States
Phone
+1 617-525-4971
Fax
+1 617-525-0040
ORCID ID
0000-0002-0492-1419
Biography and Research Interest
Developmental biology of erythroid commitment and differentiation. Our research is focused on studying genes important for erythropoiesis. Using zebrafish as a model organism, we perform genetic screens to isolate anemic mutants. The disrupted genes are identified by positional cloning strategies. The functions of the identified genes are studied in zebrafish and complementary systems (cultured cells, transgenic mice, yeast).
Publications
Non-Zebrafish Publications
Blanc L, Ciciotte SL, Gwynn B, Hildick-Smith GJ, Pierce EL, Soltis KA, Cooney JD, Paw BH, Peters LL. Critical function for Rasa3 in vertebrate erythropoiesis and megakaryopoiesis. Proc. Natl. Acad. Sci. USA 2012; 109:12099-12104.

Troadec MB, Warner D, Wallace J, Thomas K, Spangrude G, Phillips J, Khalimonchuk O, Paw BH, Ward DM, Kaplan J. Targeted deletion of the mouse Mitoferrn1 gene: from anemia to protoporphyria. Blood 2011; 117:5494-5502. (Cover Illustration)

Saslowsky DE, Cho JA, Chinnapen H, Massol RH, Chinnapen DJF, Wagner JS, De Luca HE, Kam W, Paw BH, Lencer WI. Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins, but not Derlin-1 or -2. J. Clin. Invest. 2010; 120:4399-4409.

Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D’Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Wei T, Orange JS, Paw BH, Weiss MJ. miR-451 protects against erythroid oxidant stress by repressing 14-3-3ζ. Genes Dev. 2010; 24:1620-33.

Chen W, Dailey HA, Paw BH. Ferrochelatase forms an oligomeric complex with mitoferrin1 and Abcb10 for erythroid heme biosynthesis. Blood 2010; 116:628-30.