Person
Lardelli, Michael
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Biography and Research Interest
ACADEMIC BACKGROUND
1984, Bachelor of Science (Honours class 1, Biology - Genetics),
University of Sydney,
Australia.
March 1991, Ph.D.
Council for National Academic Awards,
United Kingdom.
RESEARCH EXPERIENCE
1984 (February-November) Honours Degree Candidate, Department of Biology, University of Sydney, Australia. Laboratory of Dr. Keith D. Brown. Regulation of K99pilin'-lac'Z gene fusions in Escherichia coli.
1985 (January-December), Research Assistant, Garvan Institute of Medical Research, Sydney, Australia. Laboratory of Dr. John Eisman. Effects of 1,25 (OH)2 vitamin D3 on breast cancer cells.
1985 (December) - 1986 (May), Research Assistant, Department of Microbiology, University of Sydney, Australia. Laboratory of Prof. Peter Reeves. Development of a human rotavirus vaccine.
1987 (April-August), Biochemistry Department, University of Oxford, U.K.. Assistant to Dr. William Brown in laboratory of Prof. Edwin Southern. Mapping of the human Y-chromosome.
1987 (September) to 1991 (March), PhD studies - Imperial Cancer Research Fund Developmental Biology Unit, Oxford, U.K.. Laboratory of Dr. David Ish-Horowicz. Regulation and function of the Drosophila pair-rule gene hairy.
1991 (March) to 1994 (July), Postdoctoral studies - The Karolinska Institute, Stockholm, Sweden. Laboratory of Dr. Urban Lendahl. Molecular genetic analysis of early mouse neural development.
1994 (July to August), Laboratory of Philip Ingham, ICRF, London, U.K.. Expression of a mouse Notch3 transgene in the zebrafish.
1994 (July) to 1995 (June), Postdoctoral studies at Uppsala University Biomedical Center, Sweden. Department of Developmental Neuroscience. Genetic studies of vertebrate development using the zebrafish.
1995 (July) to 1997 (May), Assistant Professor at Uppsala University Biomedical Center, Sweden. Department of Developmental Neuroscience. Genetic studies of vertebrate development using the zebrafish.
1997 (June onwards), Lecturer in Genetics (tenured since 2000) in the Department of Molecular Bioscience of The University of Adelaide, Australia. Genetic studies of vertebrate development using the zebrafish.
2003 onwards, Senior Lecturer in Genetics in the Department of Molecular Bioscience of The University of Adelaide, Australia. Genetic studies of vertebrate development using the zebrafish.
2015 onwards, Associate Professor in Genetics, Alzheimer's Disease Genetics Laboratory, Centre for Molecular Pathology, School of Biological Sciences, The University of Adelaide, Australia. Investigating the molecular basis of Alzheimer's disease using zebrafish.
CURRENT RESEARCH INTERESTS
- Investigation of the molecular basis of Alzheimer's disease
- Presenilin genes, APP, Notch signalling
1984, Bachelor of Science (Honours class 1, Biology - Genetics),
University of Sydney,
Australia.
March 1991, Ph.D.
Council for National Academic Awards,
United Kingdom.
RESEARCH EXPERIENCE
1984 (February-November) Honours Degree Candidate, Department of Biology, University of Sydney, Australia. Laboratory of Dr. Keith D. Brown. Regulation of K99pilin'-lac'Z gene fusions in Escherichia coli.
1985 (January-December), Research Assistant, Garvan Institute of Medical Research, Sydney, Australia. Laboratory of Dr. John Eisman. Effects of 1,25 (OH)2 vitamin D3 on breast cancer cells.
1985 (December) - 1986 (May), Research Assistant, Department of Microbiology, University of Sydney, Australia. Laboratory of Prof. Peter Reeves. Development of a human rotavirus vaccine.
1987 (April-August), Biochemistry Department, University of Oxford, U.K.. Assistant to Dr. William Brown in laboratory of Prof. Edwin Southern. Mapping of the human Y-chromosome.
1987 (September) to 1991 (March), PhD studies - Imperial Cancer Research Fund Developmental Biology Unit, Oxford, U.K.. Laboratory of Dr. David Ish-Horowicz. Regulation and function of the Drosophila pair-rule gene hairy.
1991 (March) to 1994 (July), Postdoctoral studies - The Karolinska Institute, Stockholm, Sweden. Laboratory of Dr. Urban Lendahl. Molecular genetic analysis of early mouse neural development.
1994 (July to August), Laboratory of Philip Ingham, ICRF, London, U.K.. Expression of a mouse Notch3 transgene in the zebrafish.
1994 (July) to 1995 (June), Postdoctoral studies at Uppsala University Biomedical Center, Sweden. Department of Developmental Neuroscience. Genetic studies of vertebrate development using the zebrafish.
1995 (July) to 1997 (May), Assistant Professor at Uppsala University Biomedical Center, Sweden. Department of Developmental Neuroscience. Genetic studies of vertebrate development using the zebrafish.
1997 (June onwards), Lecturer in Genetics (tenured since 2000) in the Department of Molecular Bioscience of The University of Adelaide, Australia. Genetic studies of vertebrate development using the zebrafish.
2003 onwards, Senior Lecturer in Genetics in the Department of Molecular Bioscience of The University of Adelaide, Australia. Genetic studies of vertebrate development using the zebrafish.
2015 onwards, Associate Professor in Genetics, Alzheimer's Disease Genetics Laboratory, Centre for Molecular Pathology, School of Biological Sciences, The University of Adelaide, Australia. Investigating the molecular basis of Alzheimer's disease using zebrafish.
CURRENT RESEARCH INTERESTS
- Investigation of the molecular basis of Alzheimer's disease
- Presenilin genes, APP, Notch signalling
Non-Zebrafish Publications
Johnson, M. A.; Misra, R.M.; Lardelli, M.; Messina, M.; Ephraums, C.; Reeves, P.R.; Bolcevic, Z.; Noel, J.S.; Hum, C.P.; Mai H.V., Dyall-Smith, M.L. and Holmes, I.H. (1989) Synthesis in Escherichia coli of the major glycoprotein of human rotavirus: analysis of the antigenic regions. Gene 84: 73-81.
Rushlow, C.A., Hogan, A., Pinchin, S.M., Howe, K.M., Lardelli, M., Ish-Horowicz, D. (1989) The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. Embo J. 8: 3095-103.
Lardelli, M. (1991) The regulation and function of the pair-rule gene hairy in Drosophila melanogaster. Ph.D. thesis, Council for National Academic Awards, U.K..
Lardelli, M.T. and Ish-Horowicz, D. (1993) The Drosophilahairy pair-rule gene regulates embryonic patterning outside its apparent stripe domains. Development 118: 255-66.
Lardelli, M. and Lendahl, U. (1993) Motch A and MotchB - two mouse Notch homologues coexpressed in a wide variety of tissues. Exp. Cell Res. 204: 364-72.
Lardelli, M. and Lendahl, U. (1994) Generating bacteriophage lambda sublibraries enriched for rare clones. BioTechniques 16: 420-22.
Lardelli, M., Dahlstrand, J. and Lendahl, U. (1994) The novel Notch homologue mouse Notch 3 lacks specific EGF-repeats and is expressed in
proliferating neuroepithelium. Mech. Dev. 46: 123-36.
Larsson, C., Lardelli, M., White, I. and Lendahl, U. (1994) The human NOTCH 1, 2 and 3 genes are located at chromosome positions 9q34, 1p13-p11 and 19p13.2-13.1 in regions of neoplasia-associated translocation. Genomics 24: 253-8.
Barlow, C., Meister, B., Lardelli, M., Lendahl, U. and Vennström, B. (1994) Thyroid Abnormalities and Hepatocellular carcinoma in mice transgenic for v-erbA. EMBO J. 13: 4241-50.
Dahlstrand, J., Lardelli, M. and Lendahl, U. (1995) Nestin mRNA expression correlates with the CNS progenitor cell state in many, but not all, regions of developing CNS. Dev. Brain Res. 84: 109-129.
Mitsiadis, T. A., Lardelli, M., Lendahl, U. and Thesleff, I. (1995) Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J. Cell Biol. 130: 407-18.
Williams, R., Lendahl, U. and Lardelli, M. (1995) Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Mech. Dev. 53: 357-68.
Lardelli, M., Williams, R. and Lendahl, U. (1995) Notch-related genes in animal development. Int. J. Dev. Biol. 39: 769-80.
Lardelli, M., Williams, R., Mitsiadis, T. A. and Lendahl, U. (1996) Expression of the Notch 3 intracellular domain in the early mouse CNS leads to an expansion of the CNS progenitor cell population and disturbed neural tube development. Mech. Dev. 59: 177-90.
Lardelli, M. (1997) Generation and PCR-screening of bacteriophage lambda sublibraries enriched for rare clones (the "sublibrary method"). in Methods in Molecular Biology, Vol. 67: PCR Cloning Protocols: From Molecular Cloning to Genetic Engineering, pages 345-55, Edited by B. A. White, Humana Press Inc., Totowa, N.J., U.S.A.
Tamme, R., Camp, E., Kortschak, R.D. and Lardelli, M. (2000) Non-specific, nested suppression PCR method for isolation of unknown flanking DNA. BioTechniques 28: 895-902.
Holland, L.Z., Abi Rached, Tamme, R., L., Holland, N.D., Kortschak, R.D., Inoko, H., Shiina, T., Burgtorf, C. and Lardelli, M. (2001) Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates. Dev. Biol. 232:493-507.
Jönsson, J.-I., Xiang, Z., Pettersson, M., Lardelli, M. and Nilsson, G. (2001) Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation. Eur J Immunol. 31: 3240-7.
Groth, C and Lardelli, M. (2002) The structure and function of vertebrate fibroblast growth factor receptor 1. Int. J. Dev. Biol. 46: 393-400.
Lardelli, M. (2002) Nonspecific, nested suppression PCR method for isolation of unknown flanking DNA (“Cold-start method”) in Methods in Molecular Biology, Vol. 192: PCR Cloning Protocols, 2nd. Ed., pages 285-99, Edited by B.-Y. Chen and H. W. Janes, Humana Press Inc., Totowa, N.J., U.S.A.
Lardelli, M. (2002) Generation and PCR-screening of bacteriophage lambda sublibraries enriched for rare clones (the "sublibrary method"). in Methods in Molecular Biology, Vol. 192: PCR Cloning Protocols, 2nd. Ed., pages 391-9, Edited by B.-Y. Chen and H. W. Janes, Humana Press Inc., Totowa, N.J., U.S.A.