Person
Duan, Cunming
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Biography and Research Interest
Dr. Duan is interested in the physiological functions of peptide growth factors and the molecular mechanisms by which they act to control animal development and growth. His current research focuses on the insulin-like growth factors, their receptors and binding proteins. Dr. Duan's research makes use of whole animal models, as well as cell culture systems. These include both mammalian and teleost fish systems. A combination of molecular, cellular, biochemical and comparative approaches is used to address physiological and evolutionary questions. Current research programs in the laboratory include: 1) the role of IGFs, their receptors and binding proteins in regulating animal growth and development; 2) molecular and cellular mechanisms by which IGFs act to control cell proliferation, differentiation and migration and 3) structural and functional conservation of insulin/IGF superfamily peptides and related molecules throughout vertebrate evolution.
Non-Zebrafish Publications
2004. Yin, P., Xu, Q., and Duan, C. Paradoxical actions of endogenous and exogenous insulin-like growth factor binding protein (IGFBP)-5 revealed by RNA interference analysis. J. Biol. Chem., in press. (published online on May 19, 2004).
2004. Xu, Q., Li, S., Zhao, Y., Maures, T.J., Yin, P., and Duan, C. (2004). Evidence that IGF binding protein-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cells. Cir. Res. 94: e46-54.
2004. Xu, Q., Yan, B., Li, S., and Duan, C. (2004). Fibronectin binds insulin-like growth factor binding protein (IGFBP)-5 and abolishes its ligand-dependent action on cell migration. J. Biol. Chem. 279: 4269-4277 (published online as 10.1074/jbc.M311586200 on Nov. 24. 2003).
2003. Hsieh. T. Gordon, R., Clemmons, D.R., Busby, W.H. Jr., and Duan, C. Regulation of the mitogenic and chemotactic responses of vascular smooth muscle cells to insulin-like growth factor (IGF)-I by local IGF binding proteins. J. Biol. Chem. 278: 42886-42892.
2003. Duan, C. The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of ERK1/2. Mol. Cell. Endocrinol. 206: 75-83.
2002. Duan, C. Specifying the cellular responses to insulin-like growth factor (IGF) signals: Role of IGF binding proteins. J. Endocrinol. 175: 41-54.
2002. Funkenstein, B.I., Tsai, W., Maures, T., and Duan, C. Ontogeny, tissue distribution, and hormonal regulation of insulin-like growth factor binding protein-2 (IGFBP-2) in a marine fish, Sparus aurata. Gen. Comp. Endocrinol. 128: 112-122.
2001. Bauchat, J.R., Busby, W.Jr., Garmany, A., Moore, J., Swanson, P., Lin, M., and Duan, C. Biochemical and functional analysis of a conserved insulin-like growth factor binding protein (IGFBP) isolated from rainbow trout hepatoma cells. J. Endocrinol., 170: 619-628.
2000. Duan, C., Bauchat, J.R. and Hsieh, T. Phosphatidylinositol 3-kinase is required for IGF-I-induced vascular smooth muscle cell proliferation and migration. Cir. Res. 86: 15-23.
1999. Yano, K., Bauchat, J.R., Limatta, M., Clemmons, D.R., and Duan, C. Down-regulation of protein kinase C inhibits insulin-like growth factor-I-induced vascular smooth muscle cell proliferation, migration and gene expression. Endocrinology 140:4622-4632.
1999. Duan, C., Limatta, M.B., and Bottum, O.L. Insulin-like growth factor (IGF)-I regulates IGF binding protein-5 expression through the Phosphatidylinositol-3-Kinase, PKB/Akt and p70 S6 Kinase Signaling Pathway pathway. J. Biol. Chem., 274:37147-37153.
1998. Duan, C. Nutritional and developmental regulation of insulin-like growth factors in fish. J. Nutr., 128: 306S-314S.
1998. Duan, C., and Clemmons, D.R. Differential expression and opposing biological effects of insulin-like growth factor binding protein-4 and -5 in vascular smooth muscle cells. J. Biol. Chem. 273:16836-16842.
1998. Zheng, B., Duan, C., and Clemmons, D.R. The effect of extracellular matrix proteins on porcine smooth muscle cell insulin-like growth factor binding protein-5 synthesis and responsiveness to IGF-I. J. Biol. Chem. 273: 8994-9000.
1997. Duan, C. The insulin-like growth factor system and its biological actions in fish. Am. Zool., 37: 489-501
1996. Duan, C., Hawes, S.B., Prevette, T., and Clemmons, D.R. Insulin-like growth factor (IGF) -I regulates IGF binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells. J. Biol. Chem. 271: 4280-4288.
1995. Duan,C., Plisetskaya, E.M. and Dickhoff, W.W. Expression of Insulin-like growth factor-I in normally and abnormally developing (stunting) coho salmon: Relationship with growth and plasma concentrations of growth hormone and insulin. Endocrinology 136: 446-452.
1995. Duan, C. and Clemmons D.R. Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression. J. Biol. Chem. 270: 24844-24851.