Lin, Sheng-Jia

As a researcher with a keen interest in neurodevelopmental disorders and hearing loss, my work focuses on using the zebrafish model to investigate the functional consequences of gene loss of function associated with these disorders. The aim of my research is to elucidate the mechanisms underlying the pathogenesis of these disorders by studying the impact of gene loss of function on the development of the nervous and auditory systems. To achieve this, I use a combination of genetic, molecular, and behavioral approaches, including genome-wide association studies, CRISPR/Cas9 gene editing, gene knockdown, transcriptomic and proteomic analyses, and behavioral assays.
The zebrafish model provides a unique opportunity to study these processes in vivo, as it allows for the visualization and manipulation of gene expression during development. By leveraging the strengths of this model, I hope to contribute to a deeper understanding of the molecular basis of neurodevelopmental disorders and hearing loss. Ultimately, this knowledge could lead to the development of novel therapeutic strategies for these conditions.