Person
Sun, Xiao-Jian
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Biography and Research Interest
Xiao-Jian Sun conducted his Ph.D. studies with Dr. Zhu Chen at the Shanghai Institute of Hematology and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and gained postdoctoral training with Dr. Robert G. Roeder at the Rockefeller University. He had also spent over three months to work with Drs. Thomas A. Look and Leonard I. Zon as a visiting student at Harvard Medical School to learn zebrafish embryonic and hematopoietic development. Xiao-Jian Sun currently serves as a Principal Investigator at the Shanghai Institute of Hematology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine. His research interest is the transcriptional and epigenetic regulation of hematopoietic stem cell and leukemia, and his scientific contributions include: (i) identification of the leukemogenic transcription factor complex AETFC; (ii) identification of the human histone H3K36 methyltransferase SETD2; and (iii) clarification of the role of basic epigenetic mechanisms in developmental stress and evolution.
Non-Zebrafish Publications
1. Dai Y, Xu A, Li J, Wu L, Yu S, Chen J, Zhao W, Sun XJ, Huang J. (2021) CytoTree: an R/Bioconductor package for analysis and visualization of flow and mass cytometry data. BMC Bioinformatics, 22(1):138.
2. Chen BY, Song J, Hu CL, Chen SB, Zhang Q, Xu CH, Wu JC, Hou D, Sun M, Zhang YL, Liu N, Yu PC, Liu P, Zong LJ, Zhang JY, Dai RF, Lan F, Huang QH, Zhang SJ, Nimer SD, Chen Z, Chen SJ, Sun XJ, Wang L. (2020) SETD2 Deficiency Accelerates MDS-associated Leukemogenesis via S100a9 in NHD13 Mice and Predicts Poor Prognosis in MDS. Blood, 135(25):2271-2285
3. Liu N, Song J, Xie Y, Wang XL, Rong B, Man N, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang JY, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L, Sun XJ. (2019) Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis. Proc. Natl. Acad. Sci. U. S. A., 116(3):890-899
4. Zhang MM, Liu N, Zhang YL, Rong B, Wang XL, Xu CH, Xie YY, Shen S, Zhu J, Nimer SD, Chen Z, Chen SJ, Roeder RG, Lan F, Wang L, Huang QH, Sun XJ. (2019) Destabilization of AETFC through C/EBPalpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation. Leukemia, 33(7):1822-1827
5. Zhang YL, Sun JW, Xie YY, Zhou Y, Liu P, Song JC, Xu CH, Wang L, Liu D, Xu AN, Chen Z, Chen SJ, Sun XJ, Huang QH. (2018) Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation. Cell Res., 28(4):476-490
6. Man N, Sun XJ, Tan Y, García-Cao M, Liu F, Cheng G, Hatlen M, Xu H, Shah R, Chastain N, Liu N, Huang G, Zhou Y, Sheng M, Song J, Yang FC, Benezra R, Nimer SD, Wang L. (2016) Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin. Blood, 127(19):2322-2326
7. Sun XJ, Wang Z, Wang L, Jiang Y, Kost N, Soong TD, Chen WY, Tang Z, Nakadai T, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, Roeder RG. (2013) A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature, 500(7460):93-97
8. Tang Z, Chen WY, Shimada M, Nguyen UT, Kim J, Sun XJ, Sengoku T, McGinty RK, Fernandez JP, Muir TW, Roeder RG. (2013) SET1 and p300 synergy, through coupled histone modifications, in transcriptional activation by p53. Cell, 154(2):297-310
9. Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD. (2011) The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science, 333(6043):765-769
10. Park JH, Sun XJ, Roeder RG. (2010) The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression. Mol. Cell Biol., 30(11):2750-2761
11. Hu M., Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z. (2010) Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc. Natl. Acad. Sci. U. S. A., 107(7):2956-2961
12. Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z. (2005) Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J. Biol. Chem., 280(42):35261-35271