Person
Witten, P. Eckhard
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Biography and Research Interest
Development, plasticity, and remodelling of skeletal tissues: bone, cartilage and teeth. Comparative developmental and evolutionary analysis at and below the cellular level. Current projects:(a) basic developmental and evolutionary processes related to tooth and vertebral column formation. (b) the prevention farmed fish from developing skeletal malformations. (c) The study human skeletal disease on zebrafish and medaka models.
Latest results, the uncoupling of bone formation and mineralisation: http://onlinelibrary.wiley.com/doi/10.1111/jfb.12870/full
IAFSB 2018
The fifth conference “Interdisciplinary Approaches in Fish Skeletal Biology” takes place in Tavira, Portugal, April 18-20, 2018.
http://iafsb.org/
Great Science at a Beautiful Location!
Latest results, the uncoupling of bone formation and mineralisation: http://onlinelibrary.wiley.com/doi/10.1111/jfb.12870/full
IAFSB 2018
The fifth conference “Interdisciplinary Approaches in Fish Skeletal Biology” takes place in Tavira, Portugal, April 18-20, 2018.
http://iafsb.org/
Great Science at a Beautiful Location!
Non-Zebrafish Publications
Witten PE, Owen MAG, Fontanillas R, Soenens M, McGurk C, Obach A (2016) Primary phosphorous-deficiency in juvenile Atlantic salmon: the uncoupling of bone formation and mineralisation. Journal of Fish Biology 88: 690-708 Open Access
Rolvien T, Nagel F, Milovanovic P, Wuertz S, Marshall PR, Jeschke A, Schmidt FN, Hahn M, Witten PE, Amling M, Busse B (2016) How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime. Proceedings of the Royal Society B – Biological Sciences, in press
Vandenplas S, Willems M, Witten PE, Hansen T, Fjelldal PG, Huysseune A (2016) Epithelial label retaining cells are absent during tooth cycling in Salmo salar and Polypterus senegalus. PloS ONE, PLOS ONE | DOI:10.1371/journal.pone.0152870 Open Access
Yu T, Witten PE, Huysseune A , Buettner A, To TT , Winkler C (2016) Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Disease Models & Mechanisms 9: 155-163 Open Access
Dean M, Ekstrom L, Ornan EM, Ballantyne J, Witten PE, Riley C, Habraken W, Omelon S (2015) Mineral homeostasis and regulation of mineralization processes in the skeletons of sharks, rays and relatives (Elasmobranchii). Seminars in Cell & Developmental Biology 46: 51-67
Seemann F, Peterson DR, Witten PE, Guo B-S, Shantanagouda AH, Ye RR, Zhang G, Au DWT (2015) Insight into the transgenerational effect of benzo[a]pyrene on bone formation in a teleost fish (Oryzias latipes).Comparative Biochemistry and Physiology. Part C, 178: 60-67
To TT, Witten PE, Huysseune A, Winkler C (2015) An adult osteopetrosis model in medaka reveals importance of osteoclast function for bone remodeling in teleost fish. Comparative Biochemistry and Physiology, Part C, 178: 68-75
Witten PE, Hall BK (2015) Teleost Skeletal Plasticity: Modulation, Adaptation, and Remodelling. Copeia, in press
Witten PE, Sire J-Y, Huysseune A (2014) Old, new and new-old concepts about the evolution of teeth. J Appl Ichthyol 30(4):636-642
Loizides M, Georgiou AN, Somarakis S, Witten PE, Koumoundouros G (2014) A new type of lordosis and vertebral body compression in Gilthead seabream (Sparus aurata Linnaeus, 1758): Aetiology, anatomy and consequences for survival. Journal of Fish Diseases 37:949–957
Poirier Stewart N, Deschamps MH, Witten PE, Le Luyer J, Proulx E, Huysseune A, Bureau DP, Vandenberg GW (2014) X-ray-based morphometrics: an approach to diagnose vertebral abnormalities in under-mineralized vertebrae of juvenile triploid all-female rainbow trout (Oncorhynchus mykiss) fed with a phosphorus deficient diet. J Appl Ichthyol 30(4):496-803
Witten PE, Hall BK, Sire J-Y, Huysseune A, Gisbert E, Rosenthal H, Laize V, Winkler C (eds.) (2014) Proceedings of the Third International Conference: Interdisciplinary Approaches in Fish Skeletal Biology. April 22–24, 2013 Tavira, Algarve, Portugal. J Appl Ichthyol 30(4):597-840
Boglione C, Gavaia P, Koumoundouros G, Gisbert E, Moren M, Fontagné S, Witten PE (2013) A review on skeletal anomalies in reared european fish larvae and juveniles. Part 1: normal and anomalous skeletogenic processes. Reviews in Aquaculture 5 (Suppl. 1): S99–S1 20 (Part 2 see: S121–S 167)
Izquierdo MS, Scolamacchia M, Betancor M, Roo J, Caballero MJ, Terova G, Witten PE (2012) Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. British Journal of Nutrition 109(10):1796-1805
To TT, Witten PE, Renn J, Bhattacharya D, Huysseune A, Winkler C (2012) Rankl induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model. Development 139:141-150
Willems B, Buettner A, Huysseune A, Renn J, Witten PE, Winkler C (2012) Conditional ablation of osteoblasts in medaka. Developmental Biology 364:128-137
Gil-Martens L, Fjelldal PG, Lock EJ, Wargelius A, Wergeland H, Witten PE, Hansen, T Waagbø R, Ørnsrud R (2012) Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) post-smolts. Aquaculture Nutrition 18(1):12-20
Witten PE, Sire J-Y, Gitelman I, Mabee PM, Rosenthal H, Laize V, Darias MJ, Winkler C (eds.) (2012) Proceedings of the Secound International Conference: Interdisciplinary Approaches in Fish Skeletal Biology. April 26–28, 2011 Tavira, Algarve, Portugal. J Appl Ichthyol 28(3): 297-488
Pais de Azevedo T, Witten PE, Huysseune A, Bensimon-Brito A, Winkler C, To TT, Palmeirim I (2012) Interrelationship and modularity of notochord and somites: A comparative view on zebrafish and chicken vertebral body development. J. Appl. Ichthyol. 28(3): 316-319
Fjelldal PG, Hansen T, Breck O, Ørnsrud R, Lock EJ, Waagbø R, Wargelius A, Witten PE (2012) Vertebral deformities in farmed Atlantic salmon (Salmo salar L.) – etiology and pathology. J. Appl. Ichthyol. 28(3):433-440
Ytteborg E, Vegusdal A, Witten PE, Berge G, Takle H, Østbye TK, Ruyter B (2010) Atlantic salmon precursor cells from white muscle differentiate into osteoblasts in vitro: Polyunsaturated fatty acids and temperature influence gene expression and PGE2 production. Biochimica et Biophysica Acta 1801:127–137
Witten PE, Huysseune A (2010) The unobtrusive majority: Mononucleated bone resorbing cells in teleost fish and mammals. J Appl Ichthyol 26(2):225-229
Huysseune A, Sire JY, Witten PE (2010) A revised hypothesis on the evolutionary origin of the vertebrate dentition. J Appl Ichthyol 26(2):152–155
Witten PE, Huysseune A, Hall BK (2010) A practical approach for the identification of the many cartilaginous tissues in teleost fish. J Appl Ichthyol 26(2):257–262
Witten PE, Huysseune A (2009) A comparative view on mechanisms and functions of skeletal remodelling in teleost fish, with special emphasis on osteoclasts and their function. Biological Reviews, 84:315-346
Witten PE, Gil-Martens L, Huysseune A, Takle H, Hjelde K (2009) Towards a classification and an understanding of developmental relationships of vertebral body malformations in Atlantic salmon (Salmo salar L.). Aquaculture, 295:6-14
Berge GM, Witten PE, Baeverfjord G, Vegusdal A, Wadsworth S, Ruyter B (2009) Diets with different n-6/n-3 fatty acid ratio in diets for juvenile Atlantic salmon, effects on growth, body composition, bone development and eicosanoid production. Aquaculture, 296:299-308
Huysseune A, Sire JY, Witten PE (2009) Evolutionary and developmental origins of the vertebrate dentition. Journal of Anatomy, 214:465-467
Huysseune A, Takle H, Soenens M, Taerwe K, Witten PE (2008) Unique and shared gene expression patterns in Atlantic salmon (Salmo salar) tooth development. Development Genes and Evolution 218:427-437
Huysseune A, Witten PE (2008) An evolutionary view on tooth development and replacement in wild Atlantic salmon (Salmo salar L.). Evolution and Development 10(1):6-14
Huysseune A, Hall BK, Witten PE (2007) Establishment, maintenance and modifications of the lower jaw dentition of wild Atlantic salmon (Salmo salar L.) throughout its life cycle. Journal Anatomy 211:471–484
Hall BK, Witten PE (2007) The Origin and Plasticity of Skeletal Tissues in Vertebrate Evolution and Development. In: Anderson JS, Sues H-D (eds), Major Transitions in Vertebrate Evolution. Indiana University Press, Bloomington, IN. 432 pages
Witten PE, Huysseune A (2007) Mechanisms of Chondrogenesis and Osteogenesis in Fins. In: Hall BK (ed.) Fins into Limbs: Evolution, Development, and Transformation. The University of Chicago Press, Chicago:79-92
Huysseune A, Witten PE (2006) Patterning of development in continuously replacing osteichthyan dentitions. Journal of Experimental Zoology (Mol Dev Evol) 306B (3):204-215
Helland S, Denstadli V, Witten P. E., Hjelde K, Storebakken T, Baeverfjord G (2006) Occurrence of hyper dense vertebrae in Atlantic salmon (Salmo salar L.) fed diets with graded levels of phytic acid. Aquaculture 261:603-614
Witten PE, Obach A, Huysseune A , Baeverfjord G (2006) Vertebrae fusion in Atlantic salmon (Salmo salar): Development, aggravation and pathways of containment. Aquaculture 258:164-172
Gil-Martens L, Witten PE, Fivelstad S, Huysseune A, Sævareid B, Obach A (2006) Impact of high water carbon dioxide levels on Atlantic salmon smolts (Salmo salar L.): Effects on bone and fish performance. Aquaculture 261 (1):80-88
Gillis JA, Witten PE, Hall BK (2006) Chondroid Bone and secondary cartilage contribute to apical dentary growth in juvenile Atlantic salmon, Salmo salar Linnaeus (1758). Journal of Fish Biology 68:1-11
Franz-Odendaal T, Hall BK, Witten PE (2006) Buried alive: how osteoblasts become osteocytes? Developmental Dynamics 235:176–190
Witten PE, Gil-Martens L, Hall BK, Huysseune A, Obach A (2005) Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny. Diseases of Aquatic Organisms 64:237-246
Legere JKD, Handrigan G, Budney L, Cole AG, Fedak T, Franz-Odendaal T, Vickaryous M, Witten PE, Hall BK (2005) Something Old, Something New: Inferring Developmental Mode from the Fossil Record. The Palaeontology Newsletter 58:26-31
Witten PE, Hall BK, Huysseune A (2005) Are breeding teeth in Atlantic salmon a component of the drastic alterations of the oral facial skeleton? Archives of oral Biology 50:213-217
Lewis LM, Lall, SP. Witten PE (2004) Morphological descriptions of the early stages of spine and vertebral development in hatchery-reared larval and juvenile Atlantic halibut (Hippoglossus hippoglossus). Aquaculture 241:47-59
Roy PK, Witten PE, Hall BK, Lall SP (2004) Effects of dietary phosphorus on bone growth and mineralisation of vertebrae in haddock (Melanogrammus aeglefinus L.). Fish Physiology & Biochemistry 2002/27:35-48
Witten PE, Hall BK (2003) Seasonal changes in the lower jaw skeleton in male Atlantic salmon (Salmo salar L.): remodelling and regression of the kype after spawning. Journal of Anatomy 203:435-450
Witten PE, Hall BK (2002) Differentiation and growth of kype skeletal tissues in anadromous male Atlantic Salmon (Salmo salar). International Journal of Developmental Biology 46:719-730
Witten PE, Hansen A, Hall BK (2001) Features of mono and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling and growth. Journal of Morphology 250:197-207
Witten PE, Villwock W, Peters N, Hall BK (2000) Resorption and bone remodeling in juvenile carp (Cyprinus carpio). Journal of Applied Ichthyology 16:254-261
Witten PE, Holliday LS, Delling G, Hall BK (1999) Immunohistochemical identification of a vacuolar proton pump (V-ATPase) in bone-resorbing cells of an advanced teleost species (Oreochromis niloticus, Teleostei, Cichlidae). Journal of Fish Biology 55:1258-1272
Witten PE (1997) Enzyme histochemical characteristics of osteoblasts and mononucleated osteoclasts in a teleost fish with acellular bone (Oreochromis niloticus, Cichlidae). Cell and Tissue Research 287:591-599
Witten PE, Villwock W (1997) Growth requires bone resorption at particular skeletal elements in a teleost fish with acellular bone (Oreochromis niloticus, Teleostei: Cichlidae). Journal of Applied Ichthyology 13 (4):149-158