Person
McConnell, Sean
|
|
Biography and Research Interest
My primary interests are in hematology and molecular genetics. As a postdoc I have initiated projects studying hematopoietic stem cells in zebrafish, and histocompatibility has been an important aspect of this model. Recently, we discovered extensive structural variation within zebrafish MHC loci, including altogether different genes mapping to the various haplotypes. These findings raise fundamental questions regarding mechanisms that preserve ancient sequence variation within the genomes of only a subset of individuals.
Non-Zebrafish Publications
Hock T.D., Liby K, Wright M.M., McConnell S., Schorpp-Kistner M., Ryan T.M., and Agarwal A. (2007) JunB and junD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J. Biol. Chem. 282(9): 6875-86
Huo Y., McConnell S.C., Liu S.R., Yang R., Zhang T.-T., Sun C.-W., Wu L.-C., and Ryan T.M. (2009) Humanized mouse model of Cooley's anemia. J. Biol. Chem. 284(8): 4889-4896
Huo Y., McConnell S.C., and Ryan T.M. (2009) Preclinical transfusion-dependent humanized mouse model of beta-thalassemia major. Blood. 113(19): 4763-4770.
Huo Y., McConnell S.C., Liu S.R., Zhang T.-T., Yang R., Ren J.X., and Ryan T.M. (2010) Humanized mouse models of Cooley's anemia: correct fetal to adult hemoglobin switching, disease onset, and pathology. Ann. N. Y. Acad. Sci. 1202: 45-51
McConnell S.C., Huo Y., Liu S.R., and Ryan T.M. (2011) Human globin knockin mice complete fetal to adult hemoglobin switching in postnatal development. Mol. Cell. Biol. 31(4): 876-83
Liu S.R., McConnell S.C., and Ryan T.M. (2013) Erythroid development in the absence of adult hemoglobin. Mol. Cell. Biol. 33(11): 2241-2251