Biography and Research Interest

Publications

Non-Zebrafish Publications

2012
NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches.
Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PLoS ONE 2012; 7(6):e39725

2011
Aberrant AKT activation drives well-differentiated liposarcoma.
Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang YX, Sioletic S, Kozakewich E, Grebliunaite R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CD, Look AT. Proc. Natl. Acad. Sci. U.S.A. 2011; 108(39):16386-91

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT. Blood 2011; 118(15):4169-73

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. Nature 2011; 471(7336):104-9

2010
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. Cancer Cell 2010; 18(4):353-66

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.
Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT. J. Clin. Oncol. 2010; 28(24):3816-23

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT. Blood 2010; 115(14):2845-51

Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea.
Grace RF, Su H, Sena L, Poussaint TY, Heeney MM, Gutierrez A. Am. J. Hematol. 2010; 85(2):135-7

Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.
Penning TM, Lee SH, Jin Y, Gutierrez A, Blair IA. J. Steroid Biochem. Mol. Biol. 2010; 121(3-5):546-55

2009
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT. Blood 2009; 114(3):647-50

2007
NOTCH and PI3K-AKT pathways intertwined.
Gutierrez A, Look AT. Cancer Cell 2007; 12(5):411-3


2000
Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range.
Singh G, Gutierrez A, Xu K, Blair IA. Anal. Chem. 2000; 72(14):3007-13