Biography and Research Interest

Publications

Non-Zebrafish Publications

Liu, C., Xu, Z., Gupta, D., and Dziarski, R. (2001). Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. Journal of Biological Chemistry, 276:34355-35222 (featured on the cover of September 14 issue), PMID: 11461926.

Xu, Z., Dziarski, R., Wang, Q., Swartz, K., Sakamoto, K.M., and Gupta, D. (2001). Bacterial peptidoglycan-induced tnf-α transcription is mediated through the transcription factors Egr-1, Elk-1, and NF-κB. Journal of Immunology, 167:6975-6982, PMID: 11739517.

Dziarski, R., Platt, K.A., Gelius, E., Steiner, H., and Gupta, D. (2003). Defect in neutrophil killing and increased susceptibility to infection with non-pathogenic Gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice. Blood, 102: 689-697 (featured in an editorial: Inside Blood), PMID: 12649138.

Wang, Z-M., Li, X., Cocklin, R.R., Wang, M., Wang, M., Fukase, K., Inamura, S., Kusumoto, K., Gupta, D., and Dziarski, R. (2003). Human peptidoglycan recognition protein-L (PGRP-L) is an N-acetylmuramoyl-L-alanine amidase. Journal of Biological Chemistry, 278:49044-49052, PMID: 14506276.

Dziarski, R., and Gupta, D. (2005). Staphylococcus aureus peptidoglycan is a Toll-like receptor 2 activator: a reevaluation. Infection and Immunity, 73:5212-5216, PMID: 16041042.

Zhang, Y., van der Fits, L., Voerman, J.S., Melief, M-J., Laman, J.D., Wang, M., Wang, H., Wang, M., Li, X., Walls, C.D., Gupta, D., and Dziarski, R. (2005). Identification of serum N-acetylmuramoyl-L-alanine amidase as liver peptidoglycan recognition protein 2. Biochimica et Biophysica Acta – Proteins and Proteomics, 1752:34-46, PMID: 16054449.

Wang, H., Gupta, D., Li, X., and Dziarski, R. (2005). Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-ala amidase) is induced in keratinocytes by bacteria through p38 kinase pathway. Infection and Immunity, 73:7216-7225, PMID: 16239516.

Lu, X., Wang, M., Qi, J., Wang, H., Li, X., Gupta, D., and Dziarski, R. (2006). Peptidoglycan recognition proteins are a new class of human bactericidal proteins. Journal of Biological Chemistry, 281:5895-5907, PMID: 16354652.

Li, X., Wang, S., Wang, H., and Gupta, D. (2006). Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors. Journal of Biological Chemistry, 281:20738-20748, PMID: 16714290.

Wang M., Liu L.H., Wang S., Li X., Lu X., Gupta D., and Dziarski R. (2007). Human peptidoglycan recognition proteins require zinc to kill both gram-positive and gram-negative bacteria and are synergistic with antibacterial peptides. Journal of Immunology, 178:3116-3125, PMID: 17312159.