Person
Koehler, Carla
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Biography and Research Interest
Our research encompasses two major areas: Understanding the mechanism of protein import into
mitochondria and determining the process by which defects in mitochondrial protein translocation
lead to disease.
A basic question in cell biology is the mechanism by which a protein reaches its correct location
within the cell. Of all the organelles in a mammalian cell, the mitochondrion is the most complex
because two membranes must be crossed. In addition to the metabolic role, the mitochondria is a
key player in many cellular processes including apoptosis, metal ion homeostasis and aging. My
specific interests lie in mitochondrial biogenesis, particularly the mechanism by which proteins are
imported into the mitochondrial inner membrane.
mitochondria and determining the process by which defects in mitochondrial protein translocation
lead to disease.
A basic question in cell biology is the mechanism by which a protein reaches its correct location
within the cell. Of all the organelles in a mammalian cell, the mitochondrion is the most complex
because two membranes must be crossed. In addition to the metabolic role, the mitochondria is a
key player in many cellular processes including apoptosis, metal ion homeostasis and aging. My
specific interests lie in mitochondrial biogenesis, particularly the mechanism by which proteins are
imported into the mitochondrial inner membrane.
Non-Zebrafish Publications