Person
González Nuñez, Veronica
|
Biography and Research Interest
We have established an emergent research group, but with solid experience, scientific background and contrastable research results. Our line of research is focused on the analysis of the molecular mechanisms that regulate opioid activity, which is involved in pain modulation and in tolerance and dependence. At present, we have broaden our field of research towards the rewards the rewards pathway, mainly related to the opioid and dopaminergic neurotransmitter systems. We are analysing the in vivo effects of drug of abuse, and we are currently collaborating in the design of novel agents targetting the reward pathway. Our research model is the zebrafish, most of our assays are conducted with embryos and the obtained results are easily extrapolated to other vertebrates. We make use of a wide range of biochemical and Molecular Biology techniques, but we also use pharmacological and Cell Biology techniques. This approach allow us to analyze different levels of biological information: the genome, epigenome, transcriptome, proteome and metabolome. In addition to developing a basic line of research, we also collaborate with other scientists from diverse fields of knowlegde,as Medicinal Chemistry, Marine Biology, or even with Medical Doctor in Public Health from University of Salamanca. This multidisciplinary approach enables us to perform translational research with future applications in different research areas. We also spend on our lecturing and management duties, as well as in the transfer of knowledge. Finally, we actively take part in many activities for the Dissemination of Science.
Non-Zebrafish Publications
Riesco M.F., Valcarce D.G., Martínez J.M., Martín I., Calderón-García A. A., Gonzalez-Nunez V., Robles V. Solea senegalensis male reproductive dysfunction: new insights on an unsolved question. Reproduction, Fertility and Development. 2019 (in press)
Gonzalez-Nunez V., Rodriguez R.E. Book chapter: Cocaine and Transcription Factors. In: The Neuroscience of Cocaine: Mechanisms And Treatment. Editor. Victor R. Preedy. Ed. Academic Press, Elsevier. 2017 (16-05-2017). eBook ISBN: 9780128037928. Hardcover ISBN: 9780128037508
Gonzalez-Nuñez V., Noriega-Prieto J.A., Rodríguez RE. Morphine modulates cell proliferation through miR133b & miR128 in the neuroblastoma SH-SY5Y cell line. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2014, 1842 (4): 566–572. DOI: 10.1016/j.bbadis.2014.01.003
Rivas Boyero A., Rodríguez Martín I., González Núñez V., Rodríguez R.E. Conceptos básicos de la estructura génica. Regulación de la expresión génica (spanish). Medicine - Programa de Formación Médica Continuada Acreditado (Ed. Elsevier Doyma. ISSN: 0304-5412) 2002, 8(82): 4385–4391. DOI: 10.1016/S0304-5412(02)70819-6