Person
Reimer, Michell M.
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Biography and Research Interest
My research interest is to understand the mechanisms of developmental and regenerative processes in the vertebrate spinal cord. Specifically, I am investigating motor neuron replacement and the beneficial roles of oligodendroglia in regeneration of the lesioned spinal cord.
My aim is to identify signal transduction pathways which play key roles in the functional recovery after spinal cord lesions.
For my experiments I use zebrafish. They are ideal to study spinal cord injury in an adult vertebrate as they successfully regain function after complete spinal cord transection, accompanied by axonal and neuronal regeneration and a complex microglial/immune system response.
My aim is to identify signal transduction pathways which play key roles in the functional recovery after spinal cord lesions.
For my experiments I use zebrafish. They are ideal to study spinal cord injury in an adult vertebrate as they successfully regain function after complete spinal cord transection, accompanied by axonal and neuronal regeneration and a complex microglial/immune system response.
Non-Zebrafish Publications
McQueen J., Reimer M.M., Holland P.R., Manso Sanz Y., McLaughlin M., Fowler J.H., Horsburgh K. (2013) Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion. (PLoS ONE 9(2): e87227. doi:10.1371/journal.pone.0087227)
Reimer M.M., McQueen J., Searcy L., Scullion G., Zonta B., Desmazieres A., Holland P.R., Smith J., Gliddon C., Wood E., Herzyk P., Brophy P., McCulloch J., Horsburgh K. (2011) Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion
J Neurosci. 31:18185-94.
Horsburgh K., Reimer M.M., Holland P., Chen G., Scullion G., Fowler J.H. (2011)
Axon-glial disruption: The link between vascular disease and Alzheimer’s disease? (Review) Biochem. Soc. Trans. 1;39(4):881-5.
Reimer M.M.
Motor neuron regeneration in the spinal cord of adult zebrafish (ISBN 978-3-8381-1706-5) Suedwestdeutscher Verlag fuer Hochschulschriften (2010)
Siebert S.*, Thomsen, S.*, Reimer M.M., Bosch T.C.G. (2005) Control of foot differentiation in Hydra: Phylogenetic footprinting indicates interaction of head, bud and foot patterning systems.
Mech. Dev. 122:998-1007. * These authors contributed equally