Person

Affolter, Markus

Person ID: ZDB-PERS-040204-3
Email: Markus.Affolter@unibas.ch
URL: http://www.biozentrum.unibas.ch/affolter/trachea/
Affiliation: Affolter Lab
Address: Abteilung Zellbiologie Biozentrum Universität Basel Klingelbergstrasse 70 Basel, 4056 Switzerland
Country: Switzerland
Phone: 41-61-267-20-77 or 41-61-267-20-72
Fax: 41-61-267-20-78
ORCID ID

Biography and Research Interest

For several years, we have been interested in how epithelial cell sheets are restructured to form branched tubular networks. As a model system, we have used the developing tracheal system in the embryo of Drosophila melanogaster. Recently, a number of similarities have shown up between tracheal development in the fly and the formation of blood vessels in the fish. Based on these observation, we intend to study blood vessel development in zebrafish, using genetic and molecular approaches combined with avant-garde live imaging.

Publications

Non-Zebrafish Publications

Ribeiro, C., Ebner, A. and Affolter, M. (2002). In Vivo Imaging Reveals Different Cellular Functions for FGF and Dpp Signaling in Tracheal Branching Morphogenesis. Developmental Cell 2, 677-683.

Affolter, M., Bellusci, S., Itoh, I., Shilo,.Thiery, J.P. and Werb, Z. (2003). Tube or Not Tube: Remodeling Epithelial Tissues by Branching Morphogenesis. Developmental Cell 4, 11-18.

Jazwinska, A., Ribeiro, C. and Affolter, M. (2003) Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Nature Cell Biology 5, 895-901.