Person
Mione, Marina
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Biography and Research Interest
Research projects:
We study the early events in cancer, focusing on molecular and cellular aspects of transformation, clonal expansion and exploitation of host resources that characterize cancer-initiating cells. We have developed powerful systems to initiate cancer in different organs and stages of development, with the goal of understanding the mechanisms of transformation, visualize transformed cells in vivo and establish platforms for genetic and chemical screens. A number of projects are carried out in the lab in collaboration with clinicians, system biologists and technologists.
We study the early events in cancer, focusing on molecular and cellular aspects of transformation, clonal expansion and exploitation of host resources that characterize cancer-initiating cells. We have developed powerful systems to initiate cancer in different organs and stages of development, with the goal of understanding the mechanisms of transformation, visualize transformed cells in vivo and establish platforms for genetic and chemical screens. A number of projects are carried out in the lab in collaboration with clinicians, system biologists and technologists.
Non-Zebrafish Publications
Mione MC, Parnavelas JG. 1994. How do developing cortical neurones know where to go? Trends Neurosci 17:443-445.Mione MC, Danevic C, Boardman P, Harris B, Parnavelas JG. 1994. Lineage analysis reveals neurotransmitter (GABA or glutamate) but not calcium-binding protein homogeneity in clonally related cortical neurons. J Neurosci 14:107-123.
Parnavelas JG, Mione MC, Lavdas A. 1995. The cell lineage of neuronal subtypes in the mammalian cerebral cortex. Ciba Found Symp 193:41-58.
Lavdas AA, Mione MC, Parnavelas JG. 1996. Neuronal clones in the cerebral cortex show morphological and neurotransmitter heterogeneity during development. Cereb Cortex 6:490-497.
Cavanagh JF, Mione MC, Pappas IS, Parnavelas JG. 1997. Basic fibroblast growth factor prolongs the proliferation of rat cortical progenitor cells in vitro without altering their cell cycle parameters. Cereb Cortex 7:293-302.
Mione MC, Cavanagh JF, Harris B, Parnavelas JG. 1997. Cell fate specification and symmetrical/asymmetrical divisions in the developing cerebral cortex. J Neurosci 17:2018-2029.
Thomaidou D*, Mione MC*, Cavanagh JF, Parnavelas JG. 1997. Apoptosis and its relation to the cell cycle in the developing cerebral cortex. J Neurosci 17:1075-1085.
Anderson S, Mione M, Yun K, Rubenstein JL. 1999. Differential origins of neocortical projection and local circuit neurons: role of Dlx genes in neocortical interneuronogenesis. Cereb Cortex 9:646-654.
Eisenstat DD, Liu JK, Mione M, Zhong W, Yu G, Anderson SA, Ghattas I, Puelles L, Rubenstein JL. 1999. DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation. J Comp Neurol 414:217-237.
Barclay J, Balaguero N*, Mione M*, Ackerman SL, Letts VA, Brodbeck J, Canti C, Meir A, Page KM, Kusumi K, Perez-Reyes E, Lander ES, Frankel WN, Gardiner RM, Dolphin AC, Rees M. 2001. Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci 21:6095-6104.