Person
Rastegar, Sepand
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Biography and Research Interest
Biography:
I have been employed at the Institute of Biological and Chemical Systems - Biological Information Processing (formerly known as ITG) since January 2005, initially as a project leader and, since 2020, as an independent group leader. Prior to joining the Karlsruhe Institute of Technology, I held the following key roles:
National Institute of Health and Medical Research Fellow (2002-2024).
Postdoctoral Researcher at IGBMC, France (2000-2002).
Obtained a Ph.D. degree from the University of Ulm, Germany (1997-2000).
Earned a Diploma from the University of Strasbourg, France (1995-1997).
Research Interests:
My research focuses on characterising the molecular mechanisms that control both embryonic and adult constitutive and regenerative neurogenesis in the zebrafish, with a particular emphasis on transcriptional regulation during these processes.
My research group is involved in two European projects: DANIO-CODE and DANIO-ReCODE. Both projects aim to annotate the functional elements of the zebrafish genome and to decipher transcriptional regulation during regeneration using advanced genomics and computational tools.
I have been employed at the Institute of Biological and Chemical Systems - Biological Information Processing (formerly known as ITG) since January 2005, initially as a project leader and, since 2020, as an independent group leader. Prior to joining the Karlsruhe Institute of Technology, I held the following key roles:
National Institute of Health and Medical Research Fellow (2002-2024).
Postdoctoral Researcher at IGBMC, France (2000-2002).
Obtained a Ph.D. degree from the University of Ulm, Germany (1997-2000).
Earned a Diploma from the University of Strasbourg, France (1995-1997).
Research Interests:
My research focuses on characterising the molecular mechanisms that control both embryonic and adult constitutive and regenerative neurogenesis in the zebrafish, with a particular emphasis on transcriptional regulation during these processes.
My research group is involved in two European projects: DANIO-CODE and DANIO-ReCODE. Both projects aim to annotate the functional elements of the zebrafish genome and to decipher transcriptional regulation during regeneration using advanced genomics and computational tools.
Non-Zebrafish Publications
Friedle, H., Rastegar, S., Paul, H., Kaufmann, E. and Knochel, W. (1998) Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos. EMBO J. 17(8):2298-2307.
Rastegar, S., Friedle, H., Frommer, G. and Knochel, W. (1999) Transcriptional regulation of Xvent homeobox genes. Mech. Dev. 81:139-149.
Hennigfeld, K.A., Rastegar, S., Adler, G. and Knochel, W. (2000) Smadl and Smad4 are components of the BMP-4 induced transcription complex of the Xvent-2B promoter. J. Biol. Chem. 275(29):21827-21835.
Hennigfeld, K.A., Friedle, H., Rastegar, S. and Knochel, W. (2002) Autoregulation of Xvent-2B: Direct interaction and functional cooperation of Xvent-2 and Smadl. J. Biol. Chem. 277:2097-2103.