Hong, Jiann-Ruey

PERSONAL INFORMATION:

Name: Jiann-Ruey Hong

Date of Birth: March 30, 1961

Place of Birth: Kaushon County

Marital Status: Married (three children)

Address: Number 128, Section 2, Academia Road, Nankang, Taipei 115,
Taiwan, R.O.C.

Telephone: 88-2-2789-9534(F), 88-2-2651-2741(H)

E-mail: JRHong@gate.sinica.edu.tw

EDUCATION:

B.S: September 1983 - June 1986, Department of Husbandry, Chinese Culture University, Taipei, Taiwan, R.O.C.

M.S: September 1989 - June 1991, Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan, R.O.C.

Ph.D: September 1994 - June 1999, Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, R.O.C.

Postdoctoral fellow: July 1999 - present, Institute of Zoology, Academia Sinica, Nankang, Taipei, Taiwan, R.O.C.

RESEARCH TOPICS:

M.S. Thesis: 'Preparation of Monoclonal Antibodies Against Human
Red Blood Cell Spectrin.'

Ph.D. Dissertation: 'Induction and Molecular Regulation of Host Cell Apoptosis by Infectious Pancreatic Necrosis Virus Infection.'

Postdoctoral Fellow: (1). Studies on a novel Bcl-2 family number VP5 that play an anti-apoptosis function in IPNV early replication cycle and up-regulate the survival factor Mcl-1. (2). Focus on the viral death gene VP3 that triggered the cell death in late replication. (3). In ViVo system: assayed the death gene function in zebrafish by microinjection.

AWARDS:

Awarded traveling expenses from Academia Sinica to Third
Programmed Cell Death Symposium, September 29 - October 3, 1999, Cold Spring Harbar Laboratory, United States of America.

Awarded traveling expenses from National Science Council to 18th International Congress of Biochemistry and Molecular Biology, July 16-20, 2000, United Kingdom.

INVITING PRESENTATION:

October 5, 1999. Biotechnology Center, University of Connecticut. 'Apoptosis induced by Infectious Pancreatic Necrosis Virus infection.'

October 7, 1999. Department of Microbiology, Oregon University. 'A New Apoptosis system by Fish Birnavirus.

PUBLICATIONS:

(A) SCI Journals:

1. J. C. Hong., T. H. Hong., J. G. Chang and T. H. Chang. 1993.
Production and Characterization of Monoclonal Antibodies Against and Spectrin Subunits. J. Formos. Med. Assoc. 92(1), 61-67. .

2. J. L Wu., J. R. Hong, C. Y. Chang., C. F. Hui., C. F. Liao
and Y. L. Hsu. 1998. Involvement of Serine Proteinase in Infectious Pancreatic Necrosis Virus Capsid Protein Maturation and NS Proteinase Cleavace in CHSE-214 Cells. J. of Fish Diseases.21:215-220.

3. J. R. Hong., T. L. Lin, Y. L. Hsu and J. L. Wu. 1998.
Apoptosis procedes necrosis of fish cell line with infectious pancreatic necrosis virus infection. Virology. 250:76-84.

4. J. R. Hong., T. L. Lin., Y. L. Hsu and J. L. Wu. 1998.
Induction of apoptosis and secondary necrosis by infectious pancreatic necrosis virus in fish embryonic cells. Journal of Fish Disease.21, 463-467.

5. J. R. Hong., Y. L. Hsu and J. L. Wu. 1999. Infectious
pancreatic necrosis virus induce apoptosis due to down-regulation the surviral factor MCL-1 in fish cell line. Virus Research 63, 75-83.

6. J. R. Hong., T. L. Lin., J. Y. Yang., Y. L. Hsu and J. L. Wu.
1999. Non-typical apoptotic morphological change in infectious pancreatic necrosis virus induced apoptosis when imaged by green fluorescent protein. Journal of Virology 73, 5056-5063.

(B) Conference, Poster, Abstract:

1. J. C. Hong., T. H. Hong., J. G. Chang and T. H. Chang. 1991.
Preparation of Monoclonal Antibodies against Spectrin of Human Erythrocytes.

2. Hong, J. C., C. Y. Chang. and J. L. Wu. 1994. Serine
Proteinase Involved in Capsid Protein(VP2) Maturation of Infectious Pancreatic Necrosis Virus (IPNV) in CHSE-214. The Ninth Joint Annual Conference of Biomedical Sciences, Taipei, p69.

3.

4. Wu, J.L., J.R. Hong, C.Y. Chang, C.F. Liao and Y.L. Hsu.
1995. Involvement of serine proteinase in infectious pancreatic necrosis virus capsid protein maturation.23rd Meeting of the Federation of the European Biochemical Societies,Basel, Switzerland, August 13-18, Abstract.

5.

6. J. R. Hong., T. L. Lin., Y. L. Hsu. and J. L. Wu. 1997. The
studies of the apoptosis of CHSE cells induced by IPNV infection. Symposium of the Fisheries Society of Taiwan. pp.126.

7. J. R. Hong., Y. L. Hsu and J. L. Wu. 1998. Infectious
pancreatic necrosis virus induce apoptosis due to down-regulation the surviral factor MCL-1 in fish cell line. 4th International Symposium on Viruses of Lower Vertebrates. 12-15 MAY. UK.

8. J. R. Hong., Y. L. Hsu. and J. L. Wu. 1998. Infectious
pancreatic necrosis virus induce apoptosis which correlate to down-regulation the survival factor MVL-1 expression in fish cell line. The 32nd Annual Meeting of The Chinese Society of Microbiology. Taiwan, R.O.C. pp.CSW-97

9. J. R. Hong, Y. L. Hsu and J. L. Wu. 1999. Cloning and
Functional Analysis of Infectious Pancreatic Necrosis Virus VP5: A novel Bcl-2 family member with Regulation Viral Expression and Anti-cell Death Activity. Third programmed cell death symposium . USA. September 29-October 3, 1999. pp. 93.

10. W. L. Wang, J. R. Hong, C. F. Weng and J. L. Wu. Hammerhead ribozymes of VP5 gene on the inhibition of infectious pancreatic virus (IPNV) expression. The fifteenth joint annual conference of biomedical sciences. Taiwan. March 25-26, 2000. pp. 148.

11. C. J. Tai, J. R. Hong and J. L. Wu. Inhibition of IPNV-induced apoptosis by its VP3 antisense RNA expression in fish cell line. The fifteenth joint annual conference of biomedical sciences, March 25-26, 2000. pp. 148.

12. Jiann-Ruey Hong and Jen-Leih Wu. A novel Bcl-2 family member from aquabirnavirus that with anti-apoptotic death function but without transmembrane domain. 18th international congress of biochemistry and molecular biology. 16-20 July, 2000. pp. 363. U.K.