ZFIN Morpholino: MO1-cxcl8b.1

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cxcl8b.1

No data available

Phenotype

Phenotype resulting from MO1-cxcl8b.1

Phenotype	Fish	Figures
intersegmental vessel morphology, abnormal	i114Tg; y1Tg + MO1-cxcl8b.1	Fig. S1 from Zuñiga-Traslaviña et al., 2017

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Phenotype of all Fish created by or utilizing MO1-cxcl8b.1

Phenotype	Fish	Conditions	Figures
caudal fin Ab1-cxcl8b.1 labeling decreased amount, abnormal	WT + MO1-cxcl8b.1	amputation: caudal fin	Fig. S2 from de Oliveira et al., 2015
whole organism decreased life span, exacerbated	WT + MO1-cxcl8b.1	bacterial treatment by injection: Salmonella enterica subsp. enterica serovar Typhimurium	Fig. 1 from de Oliveira et al., 2015
neutrophil chemotaxis decreased occurrence, abnormal	WT + MO1-cxcl8b.1	amputation: caudal fin	Fig. 1 from de Oliveira et al., 2015
neutrophil chemotaxis decreased occurrence, abnormal	i114Tg + MO1-cxcl8b.1	amputation: caudal fin	Fig. 1, Fig. 3 from de Oliveira et al., 2015
leukocyte migration involved in inflammatory response process quality, abnormal	i114Tg + MO1-cxcl8b.1	physical alteration: caudal fin	Fig. 2, Fig. 4, Fig. 5, Fig. 6 from de Oliveira et al., 2013

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Citations

Include unpublished citations

Coombs, C., Georgantzoglou, A., Walker, H.A., Patt, J., Merten, N., Poplimont, H., Busch-Nentwich, E.M., Williams, S., Kotsi, C., Kostenis, E., Sarris, M. (2019) Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish. Nature communications. 10:5166
Zuñiga-Traslaviña, C., Bravo, K., Reyes, A.E., Feijóo, C.G. (2017) Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish. Journal of immunology research. 2017:6530531
de Oliveira, S., Boudinot, P., Calado, Â., Mulero, V. (2015) Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications. Journal of immunology (Baltimore, Md. : 1950). 194(4):1523-33
de Oliveira, S., Lopez-Muñoz, A., Martínez-Navarro, F.J., Galindo-Villegas, J., Mulero, V., Calado, A. (2015) Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium. Developmental and comparative immunology. 49:44-48
Elks, P.M., van der Vaart, M., van Hensbergen, V., Schutz, E., Redd, M.J., Murayama, E., Spaink, H.P., Meijer, A.H. (2014) Mycobacteria Counteract a TLR-Mediated Nitrosative Defense Mechanism in a Zebrafish Infection Model. PLoS One. 9:e100928
de Oliveira, S., Reyes-Aldasoro, C.C., Candel, S., Renshaw, S.A., Mulero, V., and Calado, A. (2013) Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response. Journal of immunology (Baltimore, Md. : 1950). 190(8):4349-59

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