ZFIN Morpholino: MO4-vegfc

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-vegfc

No data available

Phenotype

Phenotype resulting from MO4-vegfc

Phenotype	Fish	Figures
motor neuron axon guidance process quality, abnormal	ml2Tg; ncv1Tg + MO4-vegfc	Fig. 6 from Kwon et al., 2013
thoracic duct aplastic, abnormal	nz150Tg + MO4-vegfc	Fig. 1 from Astin et al., 2014
thoracic duct lymphangiogenesis decreased process quality, abnormal	nz150Tg + MO4-vegfc	Fig. 1 from Astin et al., 2014

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Phenotype of all Fish created by or utilizing MO4-vegfc

Phenotype	Fish	Conditions	Figures
lymph vessel development disrupted, abnormal	WT + MO3-vegfc + MO4-vegfc	standard conditions	Fig. 6 from Flores et al., 2010
thoracic duct lymphangiogenesis decreased process quality, abnormal	nz150Tg + MO4-vegfc	standard conditions	Fig. 1 from Astin et al., 2014
thoracic duct aplastic, abnormal	nz150Tg + MO4-vegfc	standard conditions	Fig. 1 from Astin et al., 2014
motor neuron axon guidance process quality, abnormal	ml2Tg; ncv1Tg + MO4-vegfc	standard conditions	Fig. 6 from Kwon et al., 2013

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Citations

Include unpublished citations

Baeyens, N., Nicoli, S., Coon, B.G., Ross, T.D., Van den Dries, K., Han, J., Lauridsen, H.M., Mejean, C.O., Eichmann, A., Thomas, J.L., Humphrey, J.D., Schwartz, M.A. (2015) Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. eLIFE. 4
Astin, J.W., Haggerty, M.J., Okuda, K.S., Le Guen, L., Misa, J.P., Tromp, A., Hogan, B.M., Crosier, K.E., Crosier, P.S. (2014) Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development (Cambridge, England). 141(13):2680-90
Kwon, H.B., Fukuhara, S., Asakawa, K., Ando, K., Kashiwada, T., Kawakami, K., Hibi, M., Kwon, Y.G., Kim, K.W., Alitalo, K., and Mochizuki, N. (2013) The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish. Development (Cambridge, England). 140(19):4081-4090
Villefranc, J.A., Nicoli, S., Bentley, K., Jeltsch, M., Zarkada, G., Moore, J.C., Gerhardt, H., Alitalo, K., and Lawson, N.D. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development (Cambridge, England). 140(7):1497-1506
Flores, M.V., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2010) Visualization of embryonic lymphangiogenesis advances the use of the zebrafish model for research in cancer and lymphatic pathologies. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2128-2135

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