ZFIN Morpholino: MO1-casp9

Target Location

Genome Build: GRCz11Chromosome: 23

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-casp9

Expressed Gene	Anatomy	Figures
nphs1	pronephric glomerulus	Fig. 2 from Pattaro et al., 2012
pax2a	pronephros	Fig. 2 from Pattaro et al., 2012
slc12a3	pronephric distal late tubule	Fig. 2 from Pattaro et al., 2012
slc20a1a	pronephric proximal convoluted tubule pronephric proximal straight tubule	Fig. 2 from Pattaro et al., 2012

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Phenotype

Phenotype resulting from MO1-casp9

Phenotype	Fish	Figures
gut edematous, abnormal	WT + MO1-casp9	Fig. 2 from Pattaro et al., 2012
heart edematous, abnormal	WT + MO1-casp9	Fig. S9 from Pattaro et al., 2012
kidney development process quality, abnormal	WT + MO1-casp9	Fig. 2 from Pattaro et al., 2012
renal filtration decreased process quality, abnormal	WT + MO1-casp9	Fig. 2 from Pattaro et al., 2012
retinal ganglion cell axon physical object quality, abnormal	WT + MO1-casp9	Fig. 1 from Campbell et al., 2013

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Phenotype of all Fish created by or utilizing MO1-casp9

Phenotype	Fish	Conditions	Figures
kidney development process quality, abnormal	WT + MO1-casp9	standard conditions	Fig. 2 from Pattaro et al., 2012
renal filtration decreased process quality, abnormal	WT + MO1-casp9	standard conditions	Fig. 2 from Pattaro et al., 2012
retinal ganglion cell axon collateral physical object quality, abnormal	WT + MO1-casp9	standard conditions	Fig. 1 , Fig. 4 from Campbell et al., 2013
retinal ganglion cell collateral sprouting in absence of injury occurrence, abnormal	WT + MO1-casp9	standard conditions	Fig. 4 from Campbell et al., 2013
gut edematous, abnormal	WT + MO1-casp9	standard conditions	Fig. 2 from Pattaro et al., 2012

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Citations

Include unpublished citations

Campbell, D.S., and Okamoto, H. (2013) Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization. The Journal of cell biology. 203(4):657-672
Espín, R., Roca, F.J., Candel, S., Sepulcre, M.P., González-Rosa, J.M., Alcaraz-Pérez, F., Meseguer, J., Cayuela, M.L., Mercader, N., and Mulero, V. (2013) TNF receptors regulate vascular homeostasis through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Disease models & mechanisms. 6(2):383-396
Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Böger, C.A., Fuchsberger, C., Olden, M., Chen, M.H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M.C., O'Seaghdha, C.M., Glazer, N., Isaacs, A., Liu, C.T., Smith, A.V., O'Connell, J.R., Struchalin, M., Tanaka, T., Li, G., Johnson, A.D., Gierman, H.J., Feitosa, M., Hwang, S.J., Atkinson, E.J., Lohman, K., Cornelis, M.C., Johansson, A., Tönjes, A., Dehghan, A., Chouraki, V., Holliday, E.G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A.Y., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Harris, T.B., Launer, L.J., Aspelund, T., Eiriksdottir, G., Mitchell, B.D., Boerwinkle, E., Schmidt, H., Cavalieri, M., Rao, M., Hu, F.B., Demirkan, A., Oostra, B.A., de Andrade, M., Turner, S.T., Ding, J., Andrews, J.S., Freedman, B.I., Koenig, W., Illig, T., Döring, A., Wichmann, H.E., Kolcic, I., Zemunik, T., Boban, M., Minelli, C., Wheeler, H.E., Igl, W., Zaboli, G., Wild, S.H., Wright, A.F., Campbell, H., Ellinghaus, D., Nöthlings, U., Jacobs, G., Biffar, R., Endlich, K., Ernst, F., Homuth, G., Kroemer, H.K., Nauck, M., Stracke, S., Völker, U., Völzke, H., Kovacs, P., Stumvoll, M., Mägi, R., Hofman, A., Uitterlinden, A.G., Rivadeneira, F., Aulchenko, Y.S., Polasek, O., Hastie, N., Vitart, V., Helmer, C., Wang, J.J., Ruggiero, D., Bergmann, S., Kähönen, M., Viikari, J., Nikopensius, T., Province, M., Ketkar, S., Colhoun, H., Doney, A., Robino, A., Giulianini, F., Krämer, B.K., Portas, L., Ford, I., Buckley, B.M., Adam, M., Thun, G.A., Paulweber, B., Haun, M., Sala, C., Metzger, M., Mitchell, P., Ciullo, M., Kim, S.K., Vollenweider, P., Raitakari, O., Metspalu, A., Palmer, C., Gasparini, P., Pirastu, M., Jukema, J.W., Probst-Hensch, N.M., Kronenberg, F., Toniolo, D., Gudnason, V., Shuldiner, A.R., Coresh, J., Schmidt, R., Ferrucci, L., Siscovick, D.S., van Duijn, C.M., Borecki, I., Kardia, S.L., Liu, Y., Curhan, G.C., Rudan, I., Gyllensten, U., Wilson, J.F., Franke, A., Pramstaller, P.P., Rettig, R., Prokopenko, I., Witteman, J.C., Hayward, C., Ridker, P., Parsa, A., Bochud, M., Heid, I.M., Goessling, W., Chasman, D.I., Kao, W.H., and Fox, C.S. (2012) Genome-wide association and functional follow-up reveals new Loci for kidney function. PLoS Genetics. 8(3):e1002584
Sidi, S., Sanda, T., Kennedy, R.D., Hagen, A.T., Jette, C.A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J.F., Kanki, J.P., Green, D.R., D'Andrea, A.A., and Look, A.T. (2008) Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3. Cell. 133(5):864-877

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