ZFIN Morpholino: MO1-fgfr1a

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-fgfr1a

Expressed Gene	Anatomy	Figures
efna3b	presumptive neural retina	Fig. 10 from Nakayama et al., 2008
enc3	forerunner cell group germ ring	Fig. 4 from Qian et al., 2013
foxj1a	forerunner cell group	Fig. 4 from Caron et al., 2012
gnrh3	olfactory system	Fig. 7 from Kuo et al., 2014
mafa	solid lens vesicle	Fig. 10 from Nakayama et al., 2008

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Phenotype

Phenotype resulting from MO1-fgfr1a

Phenotype	Fish	Figures
cranial nerve I axon mislocalised, abnormal	rw037Tg + MO1-fgfr1a	Fig. 4 from Garaffo et al., 2013
hindbrain apoptotic process increased process quality, abnormal	AB + MO1-fgfr1a	Fig. 3 from Wu et al., 2021
Kupffer's vesicle cilium decreased amount, abnormal	WT + MO1-fgfr1a	Fig. 4 from Liu et al., 2011
Kupffer's vesicle cilium decreased length, abnormal	WT + MO1-fgfr1a	Fig. 3 from Gao et al., 2017 Fig. 4 from Liu et al., 2011
olfactory bulb glomerulus malformed, abnormal	rw037Tg + MO1-fgfr1a	Fig. 4 from Garaffo et al., 2013

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Phenotype of all Fish created by or utilizing MO1-fgfr1a

Phenotype	Fish	Conditions	Figures
hindbrain apoptotic process increased process quality, abnormal	AB + MO1-fgfr1a	control	Fig. 3 from Wu et al., 2021
rhombomere 7 cranial motor neuron decreased amount, abnormal	AB + MO1-fgfr1a	control	Fig. 4 from Wu et al., 2021
Kupffer's vesicle cilium decreased length, abnormal	TU + MO1-fgfr1a	standard conditions	Fig. 3 from Gao et al., 2017
Kupffer's vesicle cilium decreased amount, abnormal	WT + MO1-fgfr1a	standard conditions	Fig. 4 from Liu et al., 2011
Kupffer's vesicle cilium decreased length, abnormal	WT + MO1-fgfr1a	standard conditions	Fig. 4 from Liu et al., 2011

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Citations

Include unpublished citations

Dries, R., Lange, A., Heiny, S., Berghaus, K.I., Bastmeyer, M., Bentrop, J. (2021) Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions. Frontiers in cell and developmental biology. 8:591011
Wu, Y., Huang, S., Zhao, H., Cao, K., Gan, J., Yang, C., Xu, Z., Li, S., Su, B. (2021) Zebrafish Minichromosome Maintenance Protein 5 Gene Regulates the Development and Migration of Facial Motor Neurons via Fibroblast Growth Factor Signaling. Developmental neuroscience. 43(2):84-94
Gao, Q., Zhang, J., Wang, X., Liu, Y., He, R., Liu, X., Wang, F., Feng, J., Yang, D., Wang, Z., Meng, A., Yan, X. (2017) The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nature communications. 8:15279
Hong, S., Hu, P., Marino, J., Hufnagel, S.B., Hopkin, R.J., Toromanović, A., Richieri-Costa, A., Ribeiro-Bicudo, L.A., Kruszka, P., Roessler, E., Muenke, M. (2016) Dominant-negative Kinase Domain Mutations in FGFR1 Can Explain the Clinical Severity of Hartsfield Syndrome. Human molecular genetics. 25(10):1912-1922
Kuo, M.W., Lou, S.W., Chung, B.C. (2014) Hedgehog-PKA Signaling and gnrh3 Regulate the Development of Zebrafish gnrh3 Neurons. PLoS One. 9:e95545
Lee, Y., Manegold, J.E., Kim, A.D., Pouget, C., Stachura, D.L., Clements, W.K., Traver, D. (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nature communications. 5:5583
Garaffo, G., Provero, P., Molineris, I., Pinciroli, P., Peano, C., Battaglia, C., Tomaiuolo, D., Etzion, T., Gothilf, Y., Santoro, M., and Merlo, G.R. (2013) Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Frontiers in Experimental Endocrinology. 4:203
Larbuisson, A., Dalcq, J., Martial, J.A., and Muller, M. (2013) Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development. Differentiation; research in biological diversity. 86(4-5):192-206
Qian, M., Yao, S., Jing, L., He, J., Xiao, C., Zhang, T., Meng, W., Zhu, H., Xu, H., and Mo, X. (2013) ENC1-like Integrates the Retinoic Acid/FGF Signaling Pathways to Modulate Ciliogenesis of Kupffer's Vesicle during Zebrafish Embryonic Development. Developmental Biology. 374(1):85-95
Samson, S.C., Ferrer, T., Jou, C.J., Sachse, F.B., Shankaran, S.S., Shaw, R.M., Chi, N.C., Tristani-Firouzi, M., and Yost, H.J. (2013) 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biology. 11(12):e1001727

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