ZFIN Morpholino: MO1-cyp1a

Target Location

Genome Build: GRCz11Chromosome: 18

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cyp1a

No data available

Phenotype

Phenotype resulting from MO1-cyp1a

No data available

Phenotype of all Fish created by or utilizing MO1-cyp1a

Phenotype	Fish	Conditions	Figures
heart morphology, ameliorated	WT + MO1-cyp1a	chemical treatment by environment: 3,3',4,4',5-pentachlorobiphenyl	Fig. 5 from Ko et al., 2012
pericardium edematous, abnormal	WT + MO1-cyp1a	chemical treatment: fossil fuel	Fig. s3 from Hicken et al., 2011
whole organism reactive oxygen species amount, ameliorated	WT + MO1-cyp1a	chemical treatment by environment: 3,3',4,4',5-pentachlorobiphenyl	Fig. 5 from Ko et al., 2012

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Citations

Include unpublished citations

Massarsky, A., Bone, A.J., Dong, W., Hinton, D.E., Prasad, G.L., Di Giulio, R.T. (2016) AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos. Toxicology and applied pharmacology. 309:63-76
Wincent, E., Kubota, A., Timme-Laragy, A., Jönsson, M.E., Hahn, M.E., Stegeman, J.J. (2016) Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochemical pharmacology. 110-111:117-29
Brown, D.R., Clark, B.W., Garner, L.V., Di Giulio, R.T. (2015) Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists. Environmental science and pollution research international. 22(11):8329-38
Zhao, B., Bohonowych, J.E., Timme-Laragy, A., Jung, D., Affatato, A.A., Rice, R.H., Di Giulio, R.T., and Denison, M.S. (2013) Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One. 8(2):e56860
Ko, S.K., and Shin, I. (2012) Cardiosulfa Induces Heart Deformation in Zebrafish through the AhR-Mediated, CYP1A-Independent Pathway. Chembiochem : a European journal of chemical biology. 13(10):1483-1489
Hicken, C.E., Linbo, T.L., Baldwin, D.H., Willis, M.L., Myers, M.S., Holland, L., Larsen, M., Stekoll, M.S., Rice, S.D., Collier, T.K., Scholz, N.L., and Incardona, J.P. (2011) Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish. Proceedings of the National Academy of Sciences of the United States of America. 108(17):7086-7090
Incardona, J.P., Linbo, T.L., and Scholz, N.L. (2011) Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development. Toxicology and applied pharmacology. 257(2):242-9
Scott, J.A., Incardona, J.P., Pelkki, K., Shepardson, S., and Hodson, P.V. (2011) AhR2-mediated, CYP1A-independent cardiovascular toxicity in zebrafish (Danio rerio) embryos exposed to retene. Aquatic toxicology (Amsterdam, Netherlands). 101(1):165-174
Timme-Laragy, A.R., Noyes, P.D., Buhler, D.R., and Di Giulio, R.T. (2008) CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Marine Environmental Research. 66(1):85-87
Billiard, S., Timme-Laragy, A.R., Wassenberg, D.M., Cockman, C., and Di Giulio, R.T. (2006) The Role of the Aryl Hydrocarbon Receptor Pathway in Mediating Synergistic Developmental Toxicity of Polycyclic Aromatic Hydrocarbons to Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 92(2):526-536

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