ZFIN Morpholino: MO1-cyp26a1

Target Location

Genome Build: GRCz11Chromosome: 12

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cyp26a1

Expressed Gene	Anatomy	Figures
dlc	segmental plate	Fig. 7 from Echeverri et al., 2007
egr2b	rhombomere 3 rhombomere 5	Fig. 3 from Li et al., 2018
her1	segmental plate	Fig. 7 from Echeverri et al., 2007
her7	segmental plate	Fig. 7 from Echeverri et al., 2007
myod1	somite	Fig. 3 from Li et al., 2018

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Phenotype

Phenotype resulting from MO1-cyp26a1

Phenotype	Fish	Figures
anterior/posterior pattern specification involved in pronephros development disrupted, abnormal	TU + MO1-cyp26a1	Fig. 5 from Naylor et al., 2016
blood circulation disrupted, abnormal	WT + MO1-cyp26a1	Fig. 7 from Echeverri et al., 2007
eye decreased size, abnormal	WT + MO1-cyp26a1	Fig. 7 from Echeverri et al., 2007
neuroectoderm znfl1 expression increased amount, abnormal	WT + MO1-cyp26a1	Fig. 4 from Li et al., 2018
neuroectoderm znfl1j expression increased amount, abnormal	WT + MO1-cyp26a1	Fig. 4 from Li et al., 2018

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Phenotype of all Fish created by or utilizing MO1-cyp26a1

Phenotype	Fish	Conditions	Figures
pronephric proximal convoluted tubule slc4a4a expression increased distribution, abnormal	TU + MO1-cyp26a1	standard conditions	Fig. 5 from Naylor et al., 2016
pronephros wholly anteriorized, abnormal	TU + MO1-cyp26a1	standard conditions	Fig. 5 from Naylor et al., 2016
pronephric distal late tubule slc12a3 expression decreased distribution, abnormal	TU + MO1-cyp26a1	standard conditions	Fig. 5 from Naylor et al., 2016
pronephric proximal straight tubule slc4a4a expression increased distribution, abnormal	TU + MO1-cyp26a1	standard conditions	Fig. 5 from Naylor et al., 2016
pronephric distal early tubule slc12a1 expression mislocalised, abnormal	TU + MO1-cyp26a1	standard conditions	Fig. 5 from Naylor et al., 2016

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Citations

Include unpublished citations

Li, J., Zhao, Y., He, L., Huang, Y., Yang, X., Yu, L., Zhao, Q., Dong, X. (2018) Znfl1s are essential for patterning the anterior-posterior axis of zebrafish posterior hindbrain by acting as direct target genes of retinoic acid. Mechanisms of Development. 155:27-33
Naylor, R.W., Skvarca, L.B., Thisse, C., Thisse, B., Hukriede, N.A., Davidson, A.J. (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nature communications. 7:12197
Sosnik, J., Zheng, L., Rackauckas, C.V., Digman, M., Gratton, E., Nie, Q., Schilling, T.F. (2016) Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. eLIFE. 5:e14034
Drummond, D.L., Cheng, C.S., Selland, L.G., Hocking, J.C., Prichard, L.B., and Waskiewicz, A.J. (2013) The role of Zic transcription factors in regulating hindbrain retinoic acid signaling. BMC Developmental Biology. 13:31
Liang, D., Jia, W., Li, J., Li, K., and Zhao, Q. (2012) Retinoic Acid signaling plays a restrictive role in zebrafish primitive myelopoiesis. PLoS One. 7(2):e30865
Kinkel, M.D., Sefton, E.M., Kikuchi, Y., Mizoguchi, T., Ward, A.B., and Prince, V.E. (2009) Cyp26 enzymes function in endoderm to regulate pancreatic field size. Proceedings of the National Academy of Sciences of the United States of America. 106(19):7864-7869
Echeverri, K., and Oates, A.C. (2007) Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism. Developmental Biology. 301(2):388-403
White, R.J., Nie, Q., Lander, A.D., and Schilling, T.F. (2007) Complex Regulation of cyp26a1 Creates a Robust Retinoic Acid Gradient in the Zebrafish Embryo. PLoS Biology. 5(11):e304
Emoto, Y., Wada, H., Okamoto, H., Kudo, A., and Imai, Y. (2005) Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish. Developmental Biology. 278(2):415-427

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